The clinical implication of serum cyclophilin A in patients with chronic obstructive pulmonary disease.
The clinical implication of serum cyclophilin A in patients with chronic obstructive pulmonary disease.
复制标题
慢性阻塞性肺疾病患者血清亲环素A检测的临床意义
DOI：
10.2147/copd.s152898
复制
发表时间：
2018
影响因子：
2.8
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhang M;Tang J;Yin J;Wang X;Feng X;Yang X;Shan H;Zhang Q;Zhang J;Li Y
亲环素A（Cyclophilin A，CyPA）是一种受炎症刺激调节的分泌性分子。虽然炎症在慢性阻塞性肺疾病（COPD）的发病机制中具有重要作用，但关于血清CyPA与COPD之间的关系知之甚少。方法93例COPD急性加重期患者纳入研究，在恢复期进行再评估。88名对照组在年龄、性别、体重指数、吸烟指数和合并症方面相匹配。收集所有参与者的基本临床信息和肺功能。进一步检测血清CyPA水平和其他炎症指标。结果COPD患者恢复期血清CyPA水平明显高于健康对照组，COPD急性加重期血清CyPA水平进一步升高。COPD急性加重期和恢复期血清CyPA与血清IL-6、MMP-9、hsCRP均呈正相关。恢复期COPD患者FEV 1/用力肺活量与FEV1%预测值呈负相关。结论血清CyPA可作为COPD患者的一个潜在炎症标志物，血清CyPA水平的测定可反映COPD患者炎症的严重程度。
Background Cyclophilin A (CyPA) is a secreted molecule that is regulated by inflammatory stimuli. Although inflammation has an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), little is known regarding the relationship between serum CyPA and COPD. Methods Ninety-three COPD patients with acute exacerbation were enrolled in the study and were reassessed during the convalescence phase. Eighty-eight controls were matched for age, gender, body mass index, smoking index and comorbidity. The basic clinical information and pulmonary function of all participants were collected. Serum levels of CyPA and other inflammation indexes were further measured. Results Serum CyPA was significantly increased in convalescent COPD patients compared to healthy controls, and further elevated in COPD patients with acute exacerbation. Serum CyPA positively correlated with serum interleukin-6, matrix metalloproteinase-9 and high-sensitivity C-reactive protein in both the exacerbation and convalescence phases of COPD. Furthermore, it negatively correlated with percent value of forced expiratory volume in 1 second (FEV1%) predicted and FEV1/forced vital capacity in convalescent COPD patients. Conclusion These results suggest that serum CyPA can be used as a potential inflammatory biomarker for COPD and assessment of serum CyPA may reflect the severity of inflammation in COPD.