Randomized Controlled Trial of Maintaining Quality of Life During Radiotherapy for Advanced Cancer
Randomized Controlled Trial of Maintaining Quality of Life During Radiotherapy for Advanced Cancer
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DOI：
10.1002/cncr.27776
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发表时间：
2013-02-15
期刊：
影响因子：
6.2
通讯作者：
Brown, Paul D.
中科院分区：
文献类型：
--
作者：
Clark, Matthew M.;Rummans, Teresa A.;Brown, Paul D.
背景技术背景：心理社会干预通常只针对生活质量（QOL）的一个领域，提供给早期癌症患者，不包括护理人员，并在癌症治疗完成后提供。方法：在目前的随机对照试验中，131名接受放疗的晚期癌症患者及其护理人员被随机分配到6个疗程的结构化多学科干预组或标准治疗组。患者平均年龄为58岁，大多数为男性（63%），肿瘤类型各不相同（胃肠道[37%]、脑[22%]、头颈部[16%]、肺[13%]和其他[12%]）。六个90分钟的会议涉及5个QOL领域：认知，身体，情感，社会和精神。现场干预之后，在接下来的6个月里进行了10次简短的电话咨询。研究结果：在完成研究的117例患者中，干预组（n = 54）第4周的总体QOL（通过癌症治疗功能评估-一般[FACT-G]评估）显著高于标准组对照组（n = 63）（75.2 vs 68.7; P = 0.02）。10次简短的电话联系似乎不影响QOL，因为在第27周，两组的QOL相同（平均值分别为77.6和77.7）。干预对护理人员生活质量没有影响。结论：参与6次多学科干预被认为是有效的维持生活质量的晚期癌症患者积极接受放疗。这一人群的生活质量和症状负担是惊人的，重要的是要确定有效的生活质量策略，实施与癌症护理。癌症2013年。(c)2012年美国癌症协会
BACKGROUND: Psychosocial interventions often address only 1 domain of quality of life (QOL), are offered to patients with early-stage cancer, do not include the caregiver, and are delivered after cancer treatment has been completed. METHODS: In the current randomized controlled trial, 131 patients with advanced cancer who received radiotherapy and their caregivers were randomly assigned to either a 6-session, structured, multidisciplinary intervention arm or a standard care arm. The average age of the patients was 58 years, the majority were male (63%), and tumor types varied (gastrointestinal [37%], brain [22%], head and neck [16%], lung [13%], and other [12%]). The six 90-minute sessions addressed the 5 domains of QOL: cognitive, physical, emotional, social, and spiritual. The in-person intervention was followed by 10 brief telephone counseling sessions that took place over the next 6 months. RESULTS: Of the 117 patients who completed the study, overall QOL (assessed by Functional Assessment of Cancer Therapy-General [FACT-G]) at week 4 was significantly higher in the intervention group (n = 54) compared with the standard arm control group (n = 63) (75.2 vs 68.7; P = .02). The 10 brief telephone contacts did not appear to impact QOL because at week 27 the groups had identical QOL (means of 77.6 and 77.7, respectively). There was no effect of the intervention noted on caregiver QOL. CONCLUSIONS: Participating in a 6-session multidisciplinary intervention was found to be effective in maintaining the QOL of patients with advanced cancer who were actively receiving radiotherapy. The QOL and symptom burden of this population is striking, making it important to identify effective QOL strategies to implement in conjunction with cancer care. Cancer 2013. (c) 2012 American Cancer Society.