Biology of neurological recovery and functional restoration after spinal cord injury
Biology of neurological recovery and functional restoration after spinal cord injury
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DOI：
10.1097/00006123-199804000-00007
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发表时间：
1998-04-01
期刊：
影响因子：
4.8
通讯作者：
Tator, CH
中科院分区：
文献类型：
--
作者：
Tator, CH
目的：本文综述了实验性或临床性脊髓损伤（SCI）后神经功能恢复的解剖学和病理生理学基础。方法：回顾了实验性或临床性SCI后神经功能恢复的现有知识，以确定神经功能恢复的生物学基础。对恢复的解剖学基础的检查表明，根部和脊髓都有可能恢复，后者涉及脊髓灰质和白色物质的恢复。急性损伤事件（如脑老化）的消退和继发性病理生理过程（如缺血和兴奋性毒性）的消退均可以解释恢复。第三个恢复机制涉及再生或再生的神经组织，导致无论是固有的或诱导processes.CONCLUSION：在十年的大脑，已经有大量的非常有前途的体外和体内的研究表明，增强神经恢复后，实验或临床SCI。
OBJECTIVE: This article reviews the anatomic and pathophysiological bases for recovery of neurological function after experimental or clinical spinal cord injury (SCI).METHODS: Current knowledge regarding the recovery of neurological function after experimental or clinical SCI was reviewed to determine the biological basis of neurological recovery.RESULTS: There is a great propensity for recovery after clinical or experimental SCI. An examination of the anatomic basis of recovery indicates that there is a potential for both root and cord recovery, with the latter involving recovery of both gray and white matter of the cord. Resolution of acute injury events, such as hemorrhaging, and resolution of secondary pathophysiological processes, such as ischemia and excitotoxicity, can each account for recovery. The third recovery mechanism involves regrowth or regeneration of nervous tissue, resulting from either inherent or induced processes.CONCLUSION: During the Decade of the Brain, there has been a profusion of very promising in vitro and in vivo studies that have shown enhanced neurological recovery after experimental or clinical SCI.