Cigarette smoking and risk for impaired fasting glucose and type 2 diabetes in middle-aged Japanese men
Cigarette smoking and risk for impaired fasting glucose and type 2 diabetes in middle-aged Japanese men
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DOI：
10.7326/0003-4819-133-3-200008010-00009
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发表时间：
2000-08-01
影响因子：
39.2
通讯作者：
Tatara, K
中科院分区：
文献类型：
--
作者：
Nakanishi, N;Nakamura, K;Tatara, K
背景资料：吸烟对空腹血糖受损和2型糖尿病的影响尚不清楚。目的：研究吸烟与空腹血糖受损和2型糖尿病的关系。设计：前瞻性队列研究。地点：日本大坂工作地点。参与者：1266名日本男性办公室职员，年龄35 - 59岁，在研究入组时没有空腹血糖受损或2型糖尿病，并且没有服用高血压药物。在1994年5月至1999年5月的年度健康检查中测量空腹血糖水平。空腹血糖受损定义为空腹血糖水平至少为6.1 mmol/L（110 mg/dL）但低于7.0 mmol/L（126 mg/dL）。2型糖尿病定义为空腹血糖水平≥ 7.0 mmol/L或目前正在接受降糖药物治疗。在5817人年和5937人年的随访中，分别有87人和54人出现空腹血糖受损和2型糖尿病。与从不吸烟者相比，空腹血糖受损的相对风险为1.62（95% CI，0.85 - 3.10）对于既往吸烟者，1.14（CI，0.58 - 2.25）吸烟1 - 20支/d者，1.33（CI，0.63至2.80）对于吸烟21至30支/d的人，和2.56（CI，1.32至4.95）对于吸烟31支或更多支/d的人（仅当前吸烟者的趋势P = 0.013）。与从不吸烟者相比，2型糖尿病的多变量调整相对风险分别为1.08（CI，0.34至3.42），1.88（CI，0.71至5.00），3.02（CI，1.15至7.94）和4.09（CI，1.62至10.29）（仅当前吸烟者的趋势P < 0.001）。暴露的包年数也与空腹血糖受损和2型糖尿病的发生呈正相关（趋势P分别为0.039和0.002）。目前吸烟者与从不吸烟者相比，体重指数小于24.2 kg/m2的男性空腹血糖受损和2型糖尿病的相对风险高于体重指数大于等于24.2 kg/m2的男性，尽管肥胖男性的绝对风险更大。在日本中年男性中，每日吸烟的数量和暴露的包年数似乎与空腹血糖受损和2型糖尿病的发生有关。
Background: The contribution of cigarette smoking to development of impaired fasting glucose and type 2 diabetes remains unclear.Objective: To investigate the association of cigarette smoking with development of impaired fasting glucose and type 2 diabetes.Design: Prospective cohort study.Setting: Work site in Osaka, Japan.Participants: 1266 Japanese male office workers 35 to 59 years of age who did not have impaired fasting glucose or type 2 diabetes and were not taking medication for hypertension at study entry.Measurements: Fasting plasma glucose levels were measured at annual health examinations from May 1994 through May 1999. Impaired fasting glucose was defined as a fasting glucose level of at least 6.1 mmol/L (110 mg/dL) but less than 7.0 mmol/L (126 mg/dL). Type 2 diabetes was defined as a fasting glucose level of 7.0 mmol/L or more or current receipt of hypoglycemic medication.Results: 87 and 54 men developed impaired fasting glucose and type 2 diabetes during 5817 and 5937 person-years follow-up, respectively After controlling for potential predictors of diabetes, the relative risk for impaired fasting glucose compared with never-smokers was 1.62 (95% CI, 0.85 to 3.10) for ever-smokers, 1.14 (CI, 0.58 to 2.25) for persons who smoked 1 to 20 cigarettes/d, 1.33 (CI, 0.63 to 2.80) for those who smoked 21 to 30 cigarettes/d, and 2.56 (CI, 1.32 to 4.95) for those who smoked 31 or more cigarettes/d (P for trend for current smokers only = 0.013). The respective multivariate-adjusted relative risks for type 2 diabetes compared with never-smokers were 1.08 (CI, 0.34 to 3.42), 1.88 (CI, 0.71 to 5.00) 3.02 (CI, 1.15 to 7.94), and 4.09 (CI, 1.62 to 10.29) (P for trend for current smokers only < 0.001). The number of pack-years of exposure was also positively related to development of impaired fasting glucose and type 2 diabetes (P for trend = 0.039 and 0.002, respectively). The relative risk for impaired fasting glucose and type 2 diabetes in current smokers versus never-smokers was stronger among men with a body mass index less than 24.2 kg/m(2) than among men with a body mass index of 24.2 kg/m(2) or more, although the absolute risk was greater in more obese men.Conclusion: The number of cigarettes smoked daily and the number of pack-years of exposure seem to be associated with development of impaired fasting glucose and type 2 diabetes in middle-aged Japanese men.