Evaluation of cartilage degeneration using multiparametric quantitative ultrashort echo time-based MRI: an ex vivo study
Evaluation of cartilage degeneration using multiparametric quantitative ultrashort echo time-based MRI: an ex vivo study
复制标题
使用多参数定量超短回波时间 MRI 评估软骨退变：一项离体研究
DOI：
10.21037/qims-21-550
复制
发表时间：
2021-11-10
影响因子：
2.8
通讯作者：
Liu, Jianjun
中科院分区：
文献类型：
--
作者：
Shao, Hongda;Yang, Jiawei;Liu, Jianjun
背景：MR定量技术发展迅速，各种MR生物标志物已显示出评估关节软骨质量的能力。本研究旨在探讨多参数定量超短回波时间（UTE）为基础的MRI评估人类软骨degeneration.Methods：20例（年龄58.8 +/- 6.6岁，6名女性）谁接受了全膝关节置换术，由于原发性骨关节炎（OA）的新鲜前外侧股骨髁样本的诊断效果。使用基于UTE的磁化转移（UTE-MT）、基于UTE的绝热T1 rho（UTE-AdiabT 1 rho）、基于UTE的T2*（UTE-T2*）和CubeQuant-T2序列对样品进行成像。根据OA研究协会国际分级和偏振光显微镜（PLM）胶原组织评分对软骨变性进行分类。使用斯皮尔曼相关性分析确定定量MRI生物标志物[UTE-MT比率（UTE-MTR）、UTE-AdiabT 1 rho、UTE-T2* 和CubeQuant-T2]、OA研究协会国际分级和PLM胶原组织评分之间的关系。结果：在定量的MRI生物标志物中，UTE-MTR与OA国际研究协会分级的相关性最强（r=-0.709，P
Background: The quantitative MR techniques developed rapidly, vary MR- biomarkers have shown the ability to assess the quality of articular cartilage. This study aimed to investigate the diagnostic efficacy of multi-parametric quantitative ultrashort echo time (UTE)-based MRI for evaluating human cartilage degeneration.Methods: Twenty fresh anterolateral femoral condyle samples were obtained from 20 patients (age, 58.8 +/- 6.6 years; 6 females) who underwent total knee arthroplasty due to primary osteoarthritis (OA). The samples were imaged using UTE-based magnetization transfer (UTE- MT), UTE-based adiabatic T1 rho (UTE-AdiabT1 rho), UTE-based T2* (UTE-T2*), and CubeQuant-T2 sequences. Cartilage degeneration was classified based on the OA Research Society International grade and polarized light microscopy (PLM) collagen organization score. Spearman's correlation analysis was used to determine the relationships between quantitative MRI biomarkers [UTE-MT ratio (UTE-MTR), UTE- AdiabT1 rho, UTE-T2*, and CubeQuant-T2], OA Research Society International grade, and PLM collagen organization score. The diagnostic efficacy of each MRI biomarker for the detection of mild cartilage degeneration was assessed using the area under the receiver operating characteristic (ROC) curve (AUC).Results: Of the quantitative MRI biomarkers, UTE-MTR had the strongest correlation with both OA Research Society International grade (r=-0.709, P