Cannabis Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples.
Cannabis Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples.
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DOI：
10.1097/ede.0000000000000314
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Anthony JC
中科院分区：
文献类型：
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作者：
Alshaarawy O;Anthony JC
在临床前动物研究中，有证据表明大麻吸烟（CS）与食欲过盛、肥胖和胰岛素抵抗有关。尽管如此，在人类中，CS可能会防止2型糖尿病（DM）。在这里，我们提供了来自（1）国家健康和营养检查调查和（2）国家药物使用和健康调查（2005-12）的8个独立重复的流行病学估计。对于每个国家调查参与者，计算机辅助自我访谈评估CS和医生诊断的DM; NHANES提供额外的生物标志物值和复合DM诊断。回归分析产生CS-DM关联的估计。荟萃分析总结了复制估计值。最近活动的CS和DM呈负相关。荟萃分析总结比值比为0.7（95% CI = 0.6，0.8）。目前的证据对于因果推断来说太弱了，但是现在有一个更稳定的证据基础，可以用于新的临床转化研究，即先前研究中提出的可能保护性（或虚假）CS-DM关联。
In preclinical animal studies, evidence links cannabis smoking (CS) with hyperphagia, obesity, and insulin resistance. Nonetheless, in humans, CS might protect against type 2 diabetes mellitus (DM). Here, we offer epidemiological estimates from eight independent replications from (1) the National Health and Nutrition Examination Surveys, and (2) the National Surveys on Drug Use and Health (2005-12). For each national survey participant, computer-assisted self-interviews assess CS and physician-diagnosed DM; NHANES provides additional biomarker values and a composite DM diagnosis. Regression analyses produce estimates of CS-DM associations. Meta-analyses summarize the replication estimates. Recently active CS and DM are inversely associated. The meta-analytic summary odds ratio is 0.7 (95% CI = 0.6, 0.8). Current evidence is too weak for causal inference, but there now is a more stable evidence base for new lines of clinical translational research on a possibly protective (or spurious) CS-DM association suggested in prior research.