Ethane production rate in vivo is reduced with dietary restriction.
Ethane production rate in vivo is reduced with dietary restriction.
复制标题
饮食限制会降低体内乙烷生成率。
DOI：
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发表时间：
1990
影响因子：
3.3
通讯作者：
A. Mooradian
中科院分区：
文献类型：
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作者：
M. Habib;F. Dickerson;A. Mooradian
没有营养不良的饮食限制可以延长寿命，并对与年龄有关的疾病和代谢紊乱有有益的影响。为了测试食物限制对乙烷生产速率的影响，我们测量了部分食物限制大鼠的乙烷呼出量。以自由采食动物食量的60%喂养2周后，室内空气乙烷产率显著降低（3.50 +/- 0.25 vs. 5.21 +/- 0.34 pmol.min-1.100 g body wt-1, P < 0.01）。在100%氧气条件下，限食大鼠的乙烷产量与自由喂养大鼠无显著差异（21.81 +/- 1.25比19.57 +/- 1.89 pmol.min-1.100 g-1）。与自由喂养相比，禁食15小时在室内空气中适度降低了乙烷产量（4.37 +/- 0.45 vs. 5.21 +/- 0.34 pmol.min-1.100 g-1），在100%氧气中更显著（12.37 +/- 0.78 vs. 19.57 +/- 1.89 pmol.min-1.100 g-1）。因此，在100%氧气条件下，与自由摄食相比，禁食15小时导致乙烷产量下降约40%。在室内空气中测量，短期食物限制显著降低了大鼠乙烷呼出率。
Dietary restriction without malnutrition prolongs life and has a beneficial effect on age-related diseases and metabolic derangements. To test the effect of food restriction on ethane production rate, ethane exhalation was measured in rats with partial food restriction. Ethane production rate in room air in rats fed 60% of food consumed by ad libitum-fed animals for 2 wk was significantly reduced (3.50 +/- 0.25 vs. 5.21 +/- 0.34 pmol.min-1.100 g body wt-1, P less than 0.01). In 100% oxygen, ethane production in food-restricted rats was not different from that of ad libitum-fed rats (21.81 +/- 1.25 vs. 19.57 +/- 1.89 pmol.min-1.100 g-1). Fifteen hours of fasting compared with ad libitum feeding reduced ethane production modestly in room air (4.37 +/- 0.45 vs. 5.21 +/- 0.34 pmol.min-1.100 g-1) and more significantly in 100% oxygen (12.37 +/- 0.78 vs. 19.57 +/- 1.89 pmol.min-1.100 g-1). Thus, in 100% oxygen, 15 h of fasting, compared with ad libitum feeding, resulted in an approximately 40% decrease in ethane production rate. It is concluded that short-term food restriction significantly reduces ethane exhalation rate in rats when measured in room air.