Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma.
Diet, physical activity, and body composition changes during the first year of treatment for childhood acute leukemia and lymphoma.
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DOI：
10.1097/mph.0b013e318279cd3e
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Demark-Wahnefried W
中科院分区：
文献类型：
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作者：
Fuemmeler BF;Pendzich MK;Clark K;Lovelady C;Rosoff P;Blatt J;Demark-Wahnefried W
接受儿童急性淋巴细胞白血病(ALL)和淋巴瘤治疗的儿童面临着几个长期健康问题的风险。ALL的幸存者和淋巴瘤的幸存者也面临肥胖的风险，这可能会进一步加剧这些问题。这项初步研究评估了正在接受ALL和淋巴瘤治疗的儿童及其父母在体力活动和身体成分方面的变化。最近确诊的青少年ALL和淋巴瘤患者来自两个儿科血液学和肿瘤学诊所，并在年龄、种族和性别上与社区健康人匹配。在基线、6个月和12个月时收集饮食、体力活动和身体成分的变化。所有儿童(n=15)入学时平均年龄为10.3岁，性别分布相当均匀。分析表明，在从基线到12个月的BMI变化方面，病例组和对照组之间存在显著差异(p=0.01)。此外，对照组的中等强度体力活动(MVPA)的增加明显大于病例组(代谢相当于任务[METS]的229.8比23.5METS)；这表明病例在治疗过程中仍然相当不活跃。我们的数据证实了之前的发现，即在对ALL和淋巴瘤进行治疗后，儿童癌症幸存者往往比健康同龄人更不活跃，患肥胖症的风险更大。这项研究在治疗的早期阶段对病例进行了12个月的前瞻性评估，通过证明这些结果在治疗的早期阶段是明显的，扩展了先前的报告。
Children who undergo treatment for childhood acute lymphoblastic leukemia (ALL) and lymphoma are at risk for several long-term health problems. Obesity, for which survivors of ALL and lymphoma are also at risk, may further exacerbate these problems. This pilot study evaluates changes in physical activity and body composition among children being treated for ALL and lymphoma and their parents. Recently diagnosed adolescent ALL and lymphoma patients were recruited from two pediatric hematology and oncology clinics, and matched on age, race, and gender to healthy individuals in the community. Changes in diet, physical activity and body composition were collected at baseline, 6, and 12 months. All children (n = 15) were, on average, 10.3 years of age at enrollment, and were fairly evenly distributed with regard to gender. Analyses revealed a significant difference between cases and controls with respect to the change in BMI from baseline to 12 months (p = 0.01). Additionally, controls demonstrated a significantly greater increase in moderate-vigorous physical activity (MVPA) than the cases (229.8 Metabolic equivalent of tasks [METs] vs. 23.5 METs); indicating cases remained fairly inactive over the course of treatment. Our data corroborate previous findings that, following treatment for ALL and lymphoma, childhood cancer survivors tend to be less active and at greater risk for obesity than their healthy peers. The present study, which assessed cases prospectively over a 12 month period during the early phases of treatment, extends prior reports by demonstrating that these outcomes are evident at an early stage in treatment.