Molecular Pathology of Alzheimer's Disease
Molecular Pathology of Alzheimer's Disease
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DOI：
10.3109/09540269309037798
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发表时间：
2013-11
期刊：
影响因子：
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通讯作者：
R. Castellani;George Perry
中科院分区：
文献类型：
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作者：
R. Castellani;George Perry
阿尔茨海默病的病理特征是两个主要的标志性病变：老年斑和神经系统缠结。自从100多年前鉴定出每种蛋白质以来，主要的蛋白质组分已经被阐明。这反过来又导致了代谢级联反应的阐述，包括老年斑中β淀粉样蛋白的产生，以及神经系统缠结中磷酸化tau蛋白的产生。近年来，每种疾病的发病机制和组织发生一直是广泛研究和一些争议的来源，因为这两个级联都涉及阿尔茨海默病的发病机制，依赖于尸检时阿尔茨海默病的诊断标准，并有针对性地进行治疗干预。随着数据的积累和阿尔茨海默病分子生物学知识的扩展，似乎对成功干预的热情还为时过早。在这本书中，我们详细介绍了...
Abstract Download Free Sample Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discove...