Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.
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DOI：
10.1161/circresaha.111.243972
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发表时间：
2012-05-11
影响因子：
20.1
通讯作者：
Griendling KK
中科院分区：
文献类型：
--
作者：
Lassègue B;San Martín A;Griendling KK
NADPH氧化酶（Nox）是心血管生理和病理生理的关键介质。这些蛋白质在几乎所有心血管细胞中表达，并调节分化、增殖、凋亡、衰老、炎症反应和氧传感等多种功能。它们靶向许多重要的信号分子，包括激酶、磷酸酶、转录因子、离子通道和调节细胞骨架的蛋白质。Nox酶与许多不同的心血管病理学有关：动脉粥样硬化、高血压、心脏肥大和重塑、血管生成和侧支形成、中风和心力衰竭。在这篇综述中，我们详细讨论了Nox酶在心血管系统（Nox 1，2，4和5）中表达的生物化学，它们在心血管细胞生物学中的作用，以及它们对疾病发展的贡献。
The NADPH oxidase (Nox) enzymes are critical mediators of cardiovascular physiology and pathophysiology. These proteins are expressed in virtually all cardiovascular cells, and regulate such diverse functions as differentiation, proliferation, apoptosis, senescence, inflammatory responses and oxygen sensing. They target a number of important signaling molecules, including kinases, phosphatases, transcription factors, ion channels and proteins that regulate the cytoskeleton. Nox enzymes have been implicated in many different cardiovascular pathologies: atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and collateral formation, stroke and heart failure. In this review, we discuss in detail the biochemistry of Nox enzymes expressed in the cardiovascular system (Nox1, 2, 4 and 5), their roles in cardiovascular cell biology, and their contributions to disease development.