Extracellular Acidosis Protects Ehrlich Ascites Tumor Cells and Rat Renal Cortex against Anoxic Injury
Extracellular Acidosis Protects Ehrlich Ascites Tumor Cells and Rat Renal Cortex against Anoxic Injury
复制标题
细胞外酸中毒保护艾氏腹水肿瘤细胞和大鼠肾皮质免受缺氧损伤
DOI：
10.1126/science.185.4147.277
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发表时间：
1974
期刊：
影响因子：
56.9
通讯作者：
B. Trump
中科院分区：
文献类型：
--
作者：
A. Penttila;B. Trump
本研究表明，细胞外酸中毒可以保护艾氏腹水肿瘤细胞和大鼠肾皮质细胞免受缺氧损伤。测量的参数包括细胞钾、5'-三磷酸腺苷和活体染料的摄取。细胞在 pH 值 5.6 至 6.5 时比在 pH 值 7.4 时存活时间更长； pH 7.9 是最有害的。这些发现表明缺氧细胞产生质子可能是一种保护性反馈机制。
The present study indicates that extracellular acidosis protects Ehrlich ascites tumor cells and rat kidney cortex cells against injury from anoxia. Parameters measured included cell potassium, adenosine 5'-triphosphate, and uptake of vital dyes. Cells survived longer at a pH of 5.6 to 6.5 than at a pH of 7.4; pH 7.9 was most detrimental. These findings indicate that production of protons by anoxic cells may be a protective feedback mechanism.