Network-level neuroplasticity in cortico-basal ganglia pathways
Network-level neuroplasticity in cortico-basal ganglia pathways
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DOI：
10.1016/j.parkreldis.2004.03.007
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发表时间：
2004-07-01
影响因子：
4.1
通讯作者：
Graybiel, AM
中科院分区：
文献类型：
--
作者：
Graybiel, AM
纹状体是基底神经节最大的输入核，接收来自新皮质和丘脑的大量输入，并产生基底神经节的直接、间接和纹状体通路。在此，人们认为纹状体是皮质基底节回路适应性可塑性的主要部位，在正常状态下影响广泛的行为。这种可塑性可能成为影响基底神经节的疾病状态中适应不良反应的主要来源。 (C) 2004 年，爱思唯尔有限公司出版。
The striatum, the largest input nucleus of the basal ganglia, receives massive inputs from the neocortex and thalamus, and gives rise to the direct, indirect and striosomal pathways of the basal ganglia. Here, the view is developed that the striatum is a major site for adaptive plasticity in cortico-basal ganglia circuits, affecting in the normal state a broad range of behaviours. This plasticity can become a major source of maladaptive responses in disease states affecting the basal ganglia. (C) 2004 Published by Elsevier Ltd.