Histaminergic systems of the limbic complex on learning and motivation
Histaminergic systems of the limbic complex on learning and motivation
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DOI：
10.1016/s0166-4328(01)00213-3
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发表时间：
2001-10-15
影响因子：
2.7
通讯作者：
Banzan, AM
中科院分区：
文献类型：
--
作者：
Alvarez, EO;Ruarte, MB;Banzan, AM
研究了海马和伏隔核中组胺敏感位点对记忆和探索动机的可能作用。作为记忆模型，使用了对预期电击的超声波的主动回避反应的学习。作为动机模型，使用了一个高架不对称十字迷宫，其臂的存在或不存在墙壁（APM）有所不同。将显微注射插管植入所有大鼠的腹侧、背侧海马或伏隔核中。在 APNI 记忆或探索测试训练试验前 5 分钟，用组胺刺激动物，无论有或没有组胺受体拮抗剂。结果表明，腹侧海马中的组胺抑制唤起，损害学习效率（累积调节反应的 37.5 +/- 6.5 与 75 +/- 5.2%；组胺与生理盐水，P < 0.01）。这种抑制作用可以被吡拉明（H-1-组胺受体拮抗剂）阻断，但不能被雷尼替丁（H-2-组胺受体拮抗剂）阻断。在背侧海马中，没有观察到组胺刺激引起的显着抑制作用。在 APM 中，伏隔核中的组胺增加了对诱发恐惧的手臂的探索（每 5 分钟计数 45 +/- 12 与 16 +/- 8；组胺与生理盐水，P < 0.01），并且还增加了情绪指数。这些作用被两种组胺受体拮抗剂阻断。总之，数据表明组胺在大鼠大脑的学习和动机/情绪过程中发挥调节作用。 (C) 2001 Elsevier Science B.V. 保留所有权利。
The possible role of histamine sensitive sites in hippocampus and the nucleus accumbens on memory and exploratory motivation was studied. As a model of memory, the learning of an active avoidance response to an ultrasonic tone anticipating an electric shock was used. As a model of motivation, an elevated asymmetric plus-maze with arms differing in the presence or absence of walls (APM) was used. All rats were implanted with microinjection cannulae into the ventral, dorsal hippocampus or the nucleus accumbens. Animals were stimulated with histamine, with or without histamine receptor antagonists 5 min before training trials in memory or exploration tests in the APNI. Results show that histamine in ventral hippocampus inhibits evocation, impairing the efficiency of learning (37.5 +/- 6.5 vs. 75 +/- 5.2% of accumulated conditioning responses; histamine vs. saline, P < 0.01). This inhibitory action was blocked by pyrilamine (H-1-histamine receptor antagonist) but not by ranitidine (H-2-histamine receptor antagonist). In dorsal hippocampus no significant inhibitory effect due to histamine stimulation was observed. In the APM, histamine in the nucleus accumbens increased exploration of the fear-inducing arms (45 +/- 12 vs. 16 +/- 8 counts per 5 min; histamine vs. saline, P < 0.01) and also increased the emotionality index. These effects were blocked by both histamine receptor antagonists. In conclusion, data suggest a modulating role for histamine in learning and motivation/emotionality processes in the rat brain. (C) 2001 Elsevier Science B.V. All rights reserved.