Effects of intracerebroventricular injection of α-fluoromethylhistidine on radial maze performance in rats
Effects of intracerebroventricular injection of α-fluoromethylhistidine on radial maze performance in rats
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DOI：
10.1016/s0091-3057(99)00128-8
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发表时间：
1999-11-01
影响因子：
3.6
通讯作者：
Kamei, C
中科院分区：
文献类型：
--
作者：
Chen, Z;Sugimoto, Y;Kamei, C
采用八臂径向迷宫实验研究了α-氟甲基组氨酸（alpha-fluoromethyl-histidine，alpha-FMH）对大鼠空间认知的影响。脑室内（ICV）注射α-FMH导致空间记忆缺陷，其特征在于总错误数（TE）增加和初始正确反应数（ICR）减少。TE数量的增加与大脑皮层和海马区组胺含量的减少之间存在很强的相关性，已知这些区域参与学习和记忆。另一方面，组胺（50-100 ng，ICV）和硫代哌丁胺（10 μ g，ICV）均显著改善α-FMH诱导的记忆缺陷。然而，甲巯嘌呤对α-FMH诱导的记忆缺陷没有显着影响。吡拉明和R-（α）-甲基组胺增强了α-FMH诱导的记忆缺陷，剂量在单独给药时没有明显的作用。相比之下，没有显着的影响，α-FMH诱导的记忆缺陷，观察到与唑兰替丁。(C)1999 Elsevier Science Inc.
The effects of alpha-fluoromethyl-histidine (alpha-FMH) on spatial cognition were investigated using the eight arm radial maze paradigm in rats. Intracerebroventricular (ICV) injection of alpha-FMH resulted in spatial memory deficits characterized by an increase in the number of total errors (TE) and a decrease in the number of initial correct responses (ICR). There was a strong correlation between increases in the number of TE and decreases in histamine contents of the cortex and hippocampus regions of the brain, which are known to participate in learning and memory. On the other hand, both histamine (50-100 ng, ICV) and thioperamide (10 mu g, ICV) significantly ameliorated the memory deficit induced by alpha-FMH. However, metoprine showed no significant effect on the alpha-FMH-induced memory deficit. Pyrilamine and R-(alpha)-methylhistamine enhanced the memory deficit induced by alpha-FMH, at doses that had no appreciable effect when administered alone. In contrast, no significant influence on alpha-FMH-induced memory deficit was observed with zolantidine. (C) 1999 Elsevier Science Inc.