Stressors interact across generations to influence offspring telomeres and survival
Stressors interact across generations to influence offspring telomeres and survival
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DOI：
10.1098/rspb.2022.0868
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发表时间：
2022-09-14
影响因子：
4.7
通讯作者：
Heidinger，Britt J.
中科院分区：
文献类型：
--
作者：
Young，Rebecca C.;Westneat，David F.;Heidinger，Britt J.
父母的压力往往会对后代产生长期的影响。然而，这些影响背后的机制以及它们如何被后代随后经历的条件所塑造，却知之甚少。端粒通常会因压力而缩短并预测寿命，可能有助于和/或反映这些跨代效应。传统上，父母的压力预计会对后代端粒产生负面影响，但对圈养动物的实验研究表明，这些影响可能取决于后代经历的后续条件。然而，在多大程度上父母的压力影响和相互作用的压力所经历的后代影响后代端粒和生存的自由生活的生物体是未知的。为了评估这一点，我们实验操纵自由生活的父母和后代的家雀（Passer arcticus）的压力暴露。我们发现，父母压力对后代端粒的影响很弱，最初是负面的，但这种影响在出生后发育结束时不再明显。相反，父母的压力的影响取决于自然的压力来源，后代经历了在出生后的发展，其中一些结果得到改善，在更紧张的饲养条件。因此，父母压力对后代端粒和生存的影响是依赖于上下文的，并可能涉及在某些情况下的潜在利益的补偿机制。
Parental stress often has long-term consequences for offspring. However, the mechanisms underlying these effects and how they are shaped by conditions offspring subsequently experience are poorly understood. Telomeres, which often shorten in response to stress and predict longevity, may contribute to, and/or reflect these cross-generational effects. Traditionally, parental stress is expected to have negative effects on offspring telomeres, but experimental studies in captive animals suggest that these effects may depend on the subsequent conditions that offspring experience. Yet, the degree to which parental stress influences and interacts with stress experienced by offspring to affect offspring telomeres and survival in free-living organisms is unknown. To assess this, we experimentally manipulated the stress exposure of free-living parent and offspring house sparrows (Passer domesticus). We found a weak, initial, negative effect of parental stress on offspring telomeres, but this effect was no longer evident at the end of post-natal development. Instead, the effects of parental stress depended on the natural sources of stress that offspring experienced during post-natal development whereby some outcomes were improved under more stressful rearing conditions. Thus, the effects of parental stress on offspring telomeres and survival are context-dependent and may involve compensatory mechanisms of potential benefit under some circumstances.