Self-awareness and self-monitoring of cognitive and behavioral deficits in behavioral variant frontotemporal dementia, primary progressive aphasia and probable Alzheimer's disease
Self-awareness and self-monitoring of cognitive and behavioral deficits in behavioral variant frontotemporal dementia, primary progressive aphasia and probable Alzheimer's disease
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DOI：
10.1016/j.bandc.2007.11.004
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发表时间：
2008-06-01
影响因子：
2.5
通讯作者：
Weintraub, Sandra
中科院分区：
文献类型：
--
作者：
Banks, Sarah;Weintraub, Sandra
缺乏自知力是行为变异型额颞叶痴呆（bvFTD）的核心诊断标准，并且被认为在原发性进行性失语（PPA）的早期阶段是完整的。在其他神经系统疾病中，已经注意到了特定的洞察力，行为症状似乎特别容易受到洞察力下降的影响。洞察力的不同组成部分，自我意识和自我监控，也经常被认为是独立的现象。当前的研究比较了PPA、bvFTD和可能患有阿尔茨海默病（PrAD）的患者和一组认知完整的对照受试者的洞察力。此外，对主要受三种类型痴呆影响的领域的洞察力差异进行了评估，即行为、记忆和记忆，并对自我意识和自我监测进行了比较。共招募了55名参与者。参与者被要求完成自我评估量表，证明他们的感知能力之前，并立即在每个领域的兴趣测试。结果表明，PPA组和正常对照组在对照（体重和视力）和认知领域的表现非常相似，而bvFTD和PrAD患者无法准确评估记忆。所有三个诊断组都未能准确评估他们的行为症状，这表明这个领域很容易在诊断中失去洞察力。相比之下，在所有组中，可测量性要么被准确评估，要么被低估。最后，自我意识和自我监控之间没有显著差异，对此进行了潜在的解释。(C)2007爱思唯尔公司All rights reserved.
Lack of insight is a core diagnostic criterion for behavioral variant frontotemporal dementia (bvFTD), and is believed to be intact in the early stages of primary progressive aphasia (PPA). In other neurological conditions, symptom-specific insight has been noted, with behavioral symptoms appearing especially vulnerable to reduced insight. Different components of insight, self-awareness and self-monitoring, are also often considered separate phenomena. The current study compared insight in patients with PPA, bvFTD, and probable Alzheimer's disease (PrAD) and a group of cognitively intact control subjects. Additionally, differences in insight for the domains primarily affected by the three types of dementia, namely, Behavior, Naming, and Memory, were assessed, and self-awareness and self-monitoring were compared. A total of 55 participants were enrolled. Participants were asked to complete self-estimate scales demonstrating their perceived ability immediately prior to, and immediately following a test in each domain of interest. Results indicated that PPA and normal control groups performed very similarly on control (Weight and Eyesight) and cognitive domains, whereas bvFTD and PrAD patients were unable to accurately assess Memory. All three diagnostic groups failed to accurately assess their behavioral symptoms, suggesting that this domain is vulnerable to loss of insight across diagnoses. Naming ability, in contrast, was either accurately assessed or underestimated in all groups. Finally, there were no notable differences between self-awareness and self-monitoring, potential explanations for this are examined. (C) 2007 Elsevier Inc. All rights reserved.