MODULATION OF THE TURNOVER RATE OF ACETYLCHOLINE IN RAT BRAIN BY INTRAVENTRICULAR INJECTIONS OF THYROTROPIN‐RELEASING HORMONE, SOMATOSTATIN, NEUROTENSIN AND ANGIOTENSIN II
MODULATION OF THE TURNOVER RATE OF ACETYLCHOLINE IN RAT BRAIN BY INTRAVENTRICULAR INJECTIONS OF THYROTROPIN‐RELEASING HORMONE, SOMATOSTATIN, NEUROTENSIN AND ANGIOTENSIN II
复制标题
脑室注射促甲状腺激素释放激素、生长抑素、神经紧张素和血管紧张素II对大鼠脑内乙酰胆碱周转率的调节
DOI：
10.1111/j.1471-4159.1978.tb07841.x
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发表时间：
1978
影响因子：
4.7
通讯作者：
E. Costa
中科院分区：
文献类型：
--
作者：
D. Malthe;P. Wood;D. Cheney;E. Costa
脑室内注射促甲状腺激素释放激素（TRH）、生长抑素、神经降压素和血管紧张素II后，测量额叶和顶叶皮层纹状体、海马、间脑和脑干的乙酰胆碱（TRACh）周转率。这些肽选择性地改变各个大脑区域的 TRACh，表明具有特定且独立的作用。这种作用的特异性也通过注射 L-脯氨酰甘氨酸、聚-L-脯氨酸和聚-L-谷氨酸进行了测试。这些合成肽都不影响 TRACh。 TRH 增加顶叶的 TRACh，但不增加额叶皮质的 TRACh，而生长抑素、神经降压素和血管紧张素 II 未能改变这些皮质区域的 TRACh。生长抑素和神经降压素会增加间脑中的 TRACh，而 TRH 和血管紧张素 II 则不会。所有四种肽都会降低顶叶皮质的乙酰胆碱 (ACh) 含量，但不会降低额叶皮质的乙酰胆碱 (ACh) 含量。只有生长抑素才能改变脑桥髓质中的 TRACh。大剂量的 TRH、神经降压素和血管紧张素 II 不能引起 TRACh 更大或更普遍的变化。相反，高剂量的生长抑素会增加海马的 TRACh 并诱导“桶状”旋转。间隔内注射生长抑素可引起长期持续的僵直症，但无法改变海马 TRACh 或引起“桶状”旋转
The turnover rate of acetylcholine (TRACh) was measured in frontal and parietal cortex striatum, hippocampus, diencephalon and brain stem following the intraventricular injection of thyrotropin‐releasing hormone (TRH), somatostatin, neurotensin and angiotensin II. These peptides selectively change the TRACh of various brain regions suggesting specific and independent actions. This specificity of action was also tested by injecting L‐prolylglycine, poly‐L‐proline and poly‐L‐glutamate. None of these synthetic peptides affect the TRACh. TRH increases the TRACh in parietal but not in frontal cortex whereas somatostatin, neurotensin and angiotensin II failed to change the TRACh in these cortical areas. Somatostatin and neurotensin increase the TRACh in diencephalon, whereas TRH and angiotensin II do not. All four peptides decrease the acetylcholine (ACh) content of parietal cortex but not that of frontal cortex. Only somatostatin changes the TRACh in pons medulla. Larger doses of TRH, neurotensin and angiotensin II fail to elicit greater or more general changes in TRACh. In contrast, high doses of somatostatin increase the TRACh of hippocampus and induce‘barrel’rotation. Intraseptal injections of somatostatin induce a long lasting catalepsy but fail to change hippocampal TRACh or to elicit‘barrel’rotation