Vaginal Stenosis After Gonadotropin-Releasing Hormone Agonist Therapy During Treatment for Acute Lymphoblastic Leukemia.
Vaginal Stenosis After Gonadotropin-Releasing Hormone Agonist Therapy During Treatment for Acute Lymphoblastic Leukemia.
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DOI：
10.1097/lgt.0000000000000175
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发表时间：
2016-04
影响因子：
3.7
通讯作者：
Masakazu Sato;M. Harada;H. Oishi;O. Wada-Hiraike;T. Hirata;K. Nagasaka;K. Koga;T. Fujii;Y. Osuga
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文献类型：
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作者：
Masakazu Sato;M. Harada;H. Oishi;O. Wada-Hiraike;T. Hirata;K. Nagasaka;K. Koga;T. Fujii;Y. Osuga
1例26岁有急性淋巴细胞性白血病化疗病史的患者，继发闭经和周期性腹痛，因阴道壁粘连导致阴道狭窄。粘连的原因被认为是由抗癌药物本身引起的阴道炎。也有人认为，化疗期间为保护卵巢而进行的促性腺激素释放激素激动剂治疗导致阴道粘膜雌激素水平低下，可能会加剧这种情况。由于我们比以往任何时候都更有可能遇到将接受或已经接受促性腺激素释放激素激动剂化疗的患者，所以敏锐的观察和适当的干预将是重要的。
A 26-year-old patient with a history of chemotherapy for acute lymphoblastic leukemia presented with secondary amenorrhea and cyclic abdominal pain, and she was found to have vaginal stenosis due to adhesion of vaginal wall. The cause of the adhesion was considered to be vaginal inflammation induced by anticancer agents themselves. It was also considered that poor estrogenization of vaginal mucosa as a result of gonadotropin-releasing hormone agonist therapy, conducted for ovarian protection during chemotherapy, might have exacerbated it. Because it is more likely than ever for us to encounter patients who will undertake or had undertaken chemotherapy with gonadotropin-releasing hormone agonist therapy, keen observation and proper intervention would be important.