HISTOCHEMICAL-STUDIES OF SYMPATHETIC SPROUTING - FLUORESCENCE MORPHOLOGY OF NORADRENERGIC AXONS
HISTOCHEMICAL-STUDIES OF SYMPATHETIC SPROUTING - FLUORESCENCE MORPHOLOGY OF NORADRENERGIC AXONS
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DOI：
10.1016/0361-9230(82)90158-7
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发表时间：
1982-01-01
影响因子：
3.8
通讯作者：
CRUTCHER, KA
中科院分区：
文献类型：
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作者：
CRUTCHER, KA
区分中枢和外周去甲肾上腺素能轴突的重要性是显而易见的，从最近的观察，交感神经纤维将侵入中枢神经系统后，特定的病变。正常的组织荧光外观的外周和中央NE [去甲肾上腺素]纤维在几个物种，以及它们的外观以下的实验操作进行审查。这两种类型的NE神经元之间最显着的差异是它们的轴突荧光形态，这显然是由靶组织决定的，以及它们对神经生长因子（NGF）的反应性。后者可能是交感神经轴突进入中枢神经系统胆碱能纤维去神经支配区域的显着增长。乙醛酸在研究这种发芽中的使用也进行了讨论。
The importance of distinguishing between central and peripheral noradrenergic axons is evident from recent observations that sympathetic fibers will invade the CNS following specific lesions. The normal histofluorescence appearance of peripheral and central NE [norepinephrine] fibers in several species as well as their appearance following experimental manipulations is reviewed. The most striking differences between these 2 types of NE neurons is their axonal fluorescence morphology, which is apparently determined by the target tissue, and their responsiveness to nerve growth factor (NGF). The latter may account for the remarkable growth of sympathetic axons into regions of the CNS denervated of cholinergic fibers. The use of glyoxylic acid in studying such sprouting is also discussed.