Inhibition of glucose oxidation by α-cyano-4-hydroxycinnamic acid stimulates feeding in rats
Inhibition of glucose oxidation by α-cyano-4-hydroxycinnamic acid stimulates feeding in rats
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DOI：
10.1016/j.physbeh.2003.10.007
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Scharrer, E
中科院分区：
文献类型：
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作者：
Del Prete, E;Lutz, TA;Scharrer, E
α-氰基-4-羟基肉桂酸（4-CIN，100-200 mg/kg b.w.），其通过抑制丙酮酸盐穿过线粒体膜的转运而损害葡萄糖氧化，在腹膜内注射后刺激大鼠进食而不影响血糖水平。与糖酵解抑制剂2-脱氧-D-葡萄糖（2-DG）一样，4-CIN可能主要通过激活α（2）-肾上腺素能受体作用于CNS，因为对4-CIN的摄食反应可被酚妥拉明或育亨宾消除。与2-DG引起的摄食不同，4-CIN诱导的摄食可通过全腹（而非肝分支）迷走神经切断术消除。由于外周阿托品化也阻断了4-CIN诱导的摄食，中枢副交感神经元的激活似乎参与了4-CIN诱导的摄食。喂食高脂饮食的大鼠对4-CIN的摄食反应减少，这可能是因为代谢传感器检测脂肪酸氧化抵消了对4-CIN的摄食反应。结果表明，通过阻断丙酮酸进入线粒体来抑制葡萄糖氧化刺激大鼠摄食，特别是当喂食高碳水化合物饮食时。(C)2003年爱思唯尔公司All rights reserved.
Alpha-cyano-4-hydroxycinnamic acid (4-CIN, 100-200 mg/kg b.wt.), which impairs glucose oxidation by inhibiting pyruvate transport across the mitochondrial membrane, stimulated feeding in rats following intraperitoneal injection without affecting blood glucose level. Like 2-deoxy-D-glucose (2-DG), an inhibitor of glycolysis, 4-CIN probably acts mainly on the CNS through activation Of alpha(2)-adrenergic receptors, because the feeding response to 4-CIN was eliminated by phentolamine or yohimbine. Unlike feeding elicited by 2-DG, 4-CIN-induced feeding was eliminated by total abdominal (but not hepatic branch) vagotomy. Since peripheral atropinization also blocked 4-CIN-induced feeding, activation of central parasympathetic neurons seems to be involved in 4-CIN-induced feeding. The feeding response to 4-CIN was diminished in rats fed a high-fat diet, probably because metabolic sensors sensing fatty acid oxidation counteract the feeding response to 4-CIN.The results suggest that inhibition of glucose oxidation by blocking pyruvate entry into mitochondria stimulates feeding in rats in particular when fed a high-carbohydrate diet. (C) 2003 Elsevier Inc. All rights reserved.