Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging
Comparison of permeability in high-grade and low-grade brain tumors using dynamic susceptibility contrast MR imaging
复制标题
DOI：
10.2214/ajr.178.3.1780711
复制
发表时间：
2002-03-01
影响因子：
5
通讯作者：
Sorensen, AG
中科院分区：
文献类型：
--
作者：
Provenzale, JM;Wang, GR;Sorensen, AG
客观的。本研究的目的是使用 T2* 加权方法比较高级别和低级别神经胶质肿瘤的渗透性测量结果。我们的假设是，使用 T2* 加权技术的渗透性测量将显示高级别肿瘤的渗透性高于低级别肿瘤的渗透性。材料和方法。 12 名活检证实的高级别肿瘤患者和 10 名活检证实的低级别肿瘤患者在推注 0.2 mmol/kg MR 造影剂后进行动态磁敏感对比 MR 灌注成像（TR/TE，1500/80）。使用一个模型创建颜色编码的通透性加权图，该模型对血管内 T2* 效应和血脑屏障通透性血管外 T1 效应对信号强度的相对贡献进行加权。进行了两种渗透性测量：在穿过肿瘤的三幅图像上发现的最高渗透性的平均值（平均区域值）和在肿瘤中的任何感兴趣区域中发现的最高值（最大渗透性的单个区域）。根据数据集的正态性，我们使用Wilcoxon的秩和检验或双尾Student's t检验进行统计分析。结果。对于低级别肿瘤，范围为 0.006-0.041，每幅图像的平均区域值的中位数为 0.017。对于高级别肿瘤，范围为 0.005-0.092，平均区域值的中位数为 0.035 (p = 0.025)。对于低级别肿瘤，范围为0.008-0.045，最大值的单个区域的平均值为0.02。对于高级别肿瘤，范围为 0.007-0.136，最大值单个区域的平均值为 0.054 (p = 0.018)。 结论。使用 T2* 加权方法获得的高级别肿瘤的渗透率值显着大于低级别肿瘤的渗透率值，并且与之前使用 T1 加权方法报告的结果一致。
OBJECTIVE. The purpose of this study was to compare permeability measurements in high-grade and low-grade glial neoplasms using a T2*-weighted method. Our hypothesis was that permeability measurements using a T2*-weighted technique would show permeability in high-grade neoplasms to be higher than that in low-grade neoplasms.MATERIALS AND METHODS. Twelve patients with biopsy-proven high-grade neoplasms and 10 patients with biopsy-proven low-grade neoplasms underwent dynamic susceptibility contrast MR perfusion imaging (TR/TE, 1500/80) after bolus infusion of 0.2 mmol/kg of MR contrast material. Color-coded permeability-weighted maps were created using a model that weights relative contributions to signal intensity from intravascular T2* effects and extravascular T1 effects from blood-brain barrier permeability. Two measures of permeability were performed: mean value of highest permeability found on three images through the tumor (mean regional value) and highest value found at any region of interest in the tumor (single area of maximum permeability). Depending on the normality of the data sets, we used the Wilcoxon's rank sum test or the two-tailed Student's t test for statistical analysis.RESULTS. For low-grade tumors, the range was 0.006-0.041, and the median of the mean regional value for each image was 0.017. For high-grade tumors, the range was 0.005-0.092, and the median of the mean regional value was 0.035 (p = 0.025). For low-grade tumors, the range was 0.008-0.045, and the mean of the single area of maximum values was 0.02. For high-grade tumors, the range was 0.007-0.136, and the mean of the single area of maximum values was 0.054 (p = 0.018).CONCLUSION. Permeability values for high-grade tumors obtained using a T2*-weighted method were significantly greater than those for low-grade tumors and are consistent with previous studies reporting results using T1-weighted methods.