A biocatalytic cascade for the conversion of fatty acids to fatty amines
A biocatalytic cascade for the conversion of fatty acids to fatty amines
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DOI：
10.1039/c9gc02260k
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发表时间：
2019-09-21
期刊：
影响因子：
9.8
通讯作者：
Turner, Nicholas J.
中科院分区：
文献类型：
--
作者：
Citoler, Joan;Derrington, Sasha R.;Turner, Nicholas J.
由可再生资源合成脂肪胺是一种需要大量能量的方法，涉及有毒金属催化剂和苛刻的反应条件以及选择性问题。在此，我们提出了一种温和的，生物催化的替代传统的胺化脂肪酸通过一锅串联级联进行的羧酸还原酶（CAR）和转氨酶（ω-TA）。饱和和不饱和脂肪酸，碳链长度范围从C-6至C-18，成功胺化获得高达96%的转化率。
Fatty amine synthesis from renewable sources is an energetically-demanding process involving toxic metal catalysts and harsh reaction conditions as well as selectivity problems. Herein we present a mild, biocatalytic alternative to the conventional amination of fatty acids through a one-pot tandem cascade performed by a carboxylic acid reductase (CAR) and a transaminase (omega-TA). Saturated and unsaturated fatty acids, with carbon chain lengths ranging from C-6 to C-18, were successfully aminated obtaining conversions of up to 96%.