Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosis
Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosis
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DOI：
10.1016/j.neulet.2013.02.038
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发表时间：
2013-04-29
影响因子：
2.5
通讯作者：
Espejo, Carmen
中科院分区：
文献类型：
--
作者：
Eixarch, Herena;Jose Mansilla, M.;Espejo, Carmen
Notch是一个参与多种组织分化的受体家族，包括中枢神经系统和免疫系统。Notch配体之一delta-样4 （Dll4）与Th1细胞的分化和Th17反应的发展有关，Th1细胞和Th17反应参与实验性自身免疫性脑脊髓炎（EAE）和多发性硬化的发病机制。我们的研究结果表明，单次给予抗dll4抗体不足以避免EAE的发展或改善已经建立的临床症状，尽管治疗降低了增殖性T细胞反应和Th1/Th17免疫反应。2013爱思唯尔爱尔兰有限公司版权所有。
Notch is a family of receptors involved in the differentiation of several tissues, including the central nervous system and the immune system. One of the Notch ligands, delta-like 4 (Dll4), has been implicated in the differentiation of Th1 cells and the development of Th17 responses, which are involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis. Our results show that a single administration of an anti-Dll4 antibody is not enough to avoid the development of EAE or to ameliorate the already established clinical signs, despite the treatment reduces the proliferative T cell responses and decreases Th1/Th17 immune responses. (C) 2013 Elsevier Ireland Ltd. All rights reserved.