Increased glomerular permeability in patients with nephropathia epidemica caused by Puumala hantavirus
Increased glomerular permeability in patients with nephropathia epidemica caused by Puumala hantavirus
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DOI：
10.1093/ndt/17.2.246
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发表时间：
2002-02-01
影响因子：
6.1
通讯作者：
Pasternack, A
中科院分区：
文献类型：
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作者：
Ala-Houhala, I;Koskinen, M;Pasternack, A
背景肾病（NE）是一种斯堪的纳维亚类型的肾综合征出血热。通常在发病时出现大量一过性蛋白尿。我们研究了8例急性NE患者和8例健康对照者的肾小球通透性。6例随访1年。以菊糖清除率测定肾小球滤过率（GFR），以对氨基马尿酸清除率测定有效肾血浆流量（ERPF）。NE患者急性期GFR和ERPF较对照组明显降低（P
Background. Nephropathia epidemica (NE) is the Scandinavian type of haemorrhagic fever with renal syndrome. Usually heavy transient proteinuria is present at the onset of the disease.Methods. We investigated glomerular permeability in eight patients with acute NE and in eight healthy controls. Six patients Were followed for 1 year. The glomerular filtration rate (GFR) was determined by inulin clearance and effective renal plasma flow (ERPF) by para-aminohippurate clearance.Results. GFR and ERPF were significantly reduced in NE patients during the acute phase compared,with those in controls (P