The Effect of Vitamin D Prophylaxis on Radiation Induced Pulmonary Damage
The Effect of Vitamin D Prophylaxis on Radiation Induced Pulmonary Damage
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DOI：
10.1269/jrr.11033
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发表时间：
2011-09-01
影响因子：
2
通讯作者：
Cengiz, Mustafa
中科院分区：
文献类型：
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作者：
Yazici, Gozde;Yildiz, Ferah;Cengiz, Mustafa
维生素D对肿瘤细胞具有选择性放射和化学增敏作用。体外和体内研究表明，维生素D抑制胶原蛋白凝胶的形成，诱导肺中II型肺细胞增殖和表面活性剂合成，并降低辐射引起的血管通透性。这项实验研究的目的是确定维生素D是否对辐射引起的肺损伤具有保护作用。成年Wistar大鼠分为4组。组I由对照动物组成。第2组为维生素D对照组，每天给予0.25 μ g/kg维生素D3，持续8周。第3组和第4组大鼠给予20戈伊，第4组在放疗前1天给予维生素D3治疗，持续8周。在研究的第8周和第12周，每组处死4只大鼠。取右肺进行光镜和电镜观察。电镜检查显示组3和组4之间差异有统计学意义，组4间质炎症和胶原沉积较少，肺泡结构和肺泡壁细胞受到保护。这些结果证实，维生素D对辐射引起的肺毒性具有保护作用。这些发现应通过进一步的临床研究进行评估。
Vitamin D has a selective radio and chemosensitizing effect on tumor cells. In vitro and in vivo studies have shown that vitamin D inhibits collagen gel construction, induces type II pneumocyte proliferation and surfactant synthesis in the lungs, and decreases vascular permeability caused by radiation. The aim of this experimental study was to determine if vitamin D has a protective effect against radiation-induced pulmonary damage. Adult Wistar rats were divided into 4 groups. Group I was comprised of control animals. Group 2, which was administered 0.25 mu g/kg/day of vitamin D3 for 8 weeks, was the vitamin D control group. Rats in groups 3 and 4 were given 20 Gy right hemithorax radiotherapy, and in addition group 4 was given vitamin D3 treatment, which began the day before the radiotherapy and continued for 8 weeks. At the 8(th) and the 12(th) weeks of the study 4 rats from each group were sacrificed. Right lungs were dissected for light and electron microscopic study. The electron microscopy examinations revealed statistically significant differences between group 3 and 4, and in group 4 there was less interstitial inflammation and collagen deposition, and the alveolar structure and the cells lining the alveolar walls were protected. These results confirm that vitamin D has a protective effect against radiation-induced pulmonary toxicity. These findings should be evaluated with further clinical studies.