ZnO nanoparticles as an oxidase mimic-mediated flow-injection chemiluminescence system for sensitive determination of carvedilol
ZnO nanoparticles as an oxidase mimic-mediated flow-injection chemiluminescence system for sensitive determination of carvedilol
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DOI：
10.1016/j.talanta.2014.06.036
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发表时间：
2014-12-01
期刊：
影响因子：
6.1
通讯作者：
Kazemi, Sayed Yahya
中科院分区：
文献类型：
--
作者：
Biparva, Pourya;Abedirad, Seyed Mohammad;Kazemi, Sayed Yahya
采用ZnO纳米颗粒（ZnO- np）扩增流动注射化学发光技术，建立了一种简便、快速、灵敏的检测非心脏选择性fl-阻滞剂卡维地洛的方法。研究发现卡维地洛对ZnO-NPs催化的鲁米诺- h2o2的化学发光有较强的抑制作用。在最佳条件下，卡维地洛浓度在5 × 10(-8) ~ 1.0 × 10(-8) mol L-1 （r > 0.9894, n=8）范围内呈线性，检出限为3.25 × 10(-9) mol L-1。8次重复性测定的相对标准偏差均小于2.9%，加样回收率分别为99%和102%。采用绿色机械化学方法合成ZnO-NPs。采用透射电镜和x射线衍射对ZnO-NPs进行表征。该方法可用于制剂中卡维地洛的检测。(C) 2014 Elsevier B.V.版权所有
A simple, rapid and sensitive method was developed using ZnO nanoparticle (ZnO-NP) amplified flow-injection chemiluminescence to detect carvedilol, a non-cardioselective fl-blocker. It has been found that carvedilol strongly inhibits the chemiluminescence of luminol-H2O2 catalyzed by ZnO-NPs. Under optimum conditions, a linear working range for carvedilol concentrations from 5 x 10(-8) to 1.0 x 10(-8) mol L-1 (r > 0.9894, n=8) was obtained with a detection limit of 3.25 x 10(-9) mol L-1. The relative standard deviation for 8 repetitive determinations was less than 2.9% and recoveries of 99% and 102% were obtained. ZnO-NPs were synthesized using a green mechanochemical route. Transmission electron microscopy and x-ray diffraction were used to characterize ZnO-NPs. The method was successfully applied to detect carvedilol in pharmaceutical formulations. (C) 2014 Elsevier B.V. All rights reserved.