Bioinspired Superwettable Microspine Chips with Directional Droplet Transportation for Biosensing
Bioinspired Superwettable Microspine Chips with Directional Droplet Transportation for Biosensing
复制标题
用于生物传感的具有定向液滴传输功能的仿生超可湿性微脊柱芯片
DOI：
10.1021/acsnano.0c00324
复制
发表时间：
2020-04-28
期刊：
影响因子：
17.1
通讯作者：
Zhang, Xueji
中科院分区：
文献类型：
--
作者：
Chen, Yanxia;Li, Kan;Zhang, Xueji
在微流控生物芯片的临床检测中，没有额外能量输入的定向液滴输送仍然是一个挑战。在此，受仙人掌刺上的集水行为的启发，我们制作了基于纳米材料的超微细刺（SMS）芯片。仿生SMS芯片能够通过协同结合几何不对称性和表面超亲水性来自发和定向液滴运输。基于理论模型，由SMS芯片的几何不对称性引起的拉普拉斯压力梯度可以支配液滴的定向输送，并且基于纳米材料的微脊的超亲水性也可以有助于液滴的自输送。多微通道SMS芯片提供了一种简单且节能的技术，可以实现对前列腺癌患者血清前列腺特异性抗原（PSA）的准确检测，显示出作为临床应用生物传感平台的巨大潜力。我们相信，我们的生物启发超二维锥形表面将提供有效的手段，智能微流控器件的设计，并在多组分生物传感和临床检测有很大的潜在应用。
Directional droplet transportation without extra energy input remains a challenge in microfluidic biochips for clinical detections. Herein, inspired by the water-collecting behaviors on the cactus spine, we fabricate nanoinaterial-based superwettable microspine (SMS) chips. The bioinspired SMS chips are capable of spontaneous and directional droplet transportation by synergistically combining geometric asymmetry and surface superhydrophilicity. Based on theoretical models, the gradient of the Laplace pressure arising from the geometric asymmetry of the SMS chip can dominate the directional transportation of the droplet, and the superhydrophilicity of the nanomaterial-based microspine can also contribute to the droplet self-transportation. The multimicrochannel SMS chips provide a simple and energy efficient technology to realize accurate detection of serum prostate-specific antigen (PSA) from prostate cancer patients, showing great potential as a biosensing platform for clinical applications. We believe that our bioinspired superwettable two-dimensional conical surface will offer effective means for the design of smart microfluidic devices and have great potential applications in multicomponent biosensing and clinical detection.