COVID-19 disparities: An urgent call for race reporting and representation in clinical research
COVID-19 disparities: An urgent call for race reporting and representation in clinical research
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DOI：
10.1016/j.conctc.2020.100630
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发表时间：
2020-09-01
影响因子：
1.5
通讯作者：
Gomez, Scarlett
中科院分区：
文献类型：
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作者：
Borno, Hala T.;Zhang, Sylvia;Gomez, Scarlett
背景：随着 SARS-CoV-2 的传播和 COVID-19 病例的激增，疾病负担方面的种族/民族差异在美国引起了人们的关注。临床研究代表性不足的问题至今仍然存在。鉴于观察到的 COVID-19 存在巨大差异，本研究旨在评估迄今为止发表的 COVID-19 治疗研究中的种族报告和代表性。方法：确定了所有已发表的与美国研究参与者有关的 COVID-19 治疗相关临床研究。对于每项研究，都记录了发表日期、调查的治疗方法、研究设计、参与者的种族/民族、样本量和研究地点。对于每个研究中心，利用公共卫生部门在线公开数据确定了确诊的 COVID-19 阳性病例的种族/族裔人口统计数据。结果：迄今为止，已发表了六项研究（n = 3，观察性；n = 3，随机临床试验）。一个子集 (n = 4) 在出版物中报告了种族/民族数据。相对于研究所在城市的受影响人群，黑人患者在所有研究中的代表性不足。结论：鉴于美国已经出现了 COVID-19 疾病负担和结果的种族/民族差异，所有研究人员必须统一报告种族/民族数据，并认真尝试获得研究参与者的代表性，以确保我们不会进一步扩大治疗范围 这次疫情期间的差距。
Background: Racial/ethnic disparities in disease burden have gained the spotlight in the United States with the spread of SARS-CoV-2 and surge of COVID-19 cases. The problem of underrepresentation in clinical research persists today. In light of the considerable COVID-19 disparities observed, this study sought to assess the race reporting and representation among COVID-19 therapeutic studies published to date.Methods: All published COVID-19 treatment-related clinical research studies with study participants in the United States were identified. For each study, the date published, treatment investigated, study design, race/ethnicity of participants, sample size and study site were recorded. For each study site, the race/ethnicity demographics of confirmed COVID-19 positive cases were identified utilizing online publicly available department of public health data.Results: Six studies (n = 3, observational; n = 3, randomized clinical trial) have been published to date with participants in the United States. A subset (n = 4) reported race/ethnicity data in the publication. Black patients were underrepresented in all studies relative to the affected population in the cities in which the studies took place.Conclusions: Given that racial/ethnic disparities in COVID-19 disease burden and outcomes have emerged in the United States, it is essential that all investigators uniformly report race/ethnicity data as well as attempt, in earnest, to obtain representativeness among study participants in order to ensure that we do not develop a further widening of the treatment gap during this pandemic.