PLASMA-CORTISOL LEVELS IN MANIA - ASSOCIATED CLINICAL RATINGS AND CHANGES DURING TREATMENT WITH HALOPERIDOL
PLASMA-CORTISOL LEVELS IN MANIA - ASSOCIATED CLINICAL RATINGS AND CHANGES DURING TREATMENT WITH HALOPERIDOL
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DOI：
10.1192/bjp.146.5.498
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发表时间：
1985-01-01
影响因子：
10.5
通讯作者：
BESSER, GM
中科院分区：
文献类型：
--
作者：
COOKSON, JC;SILVERSTONE, T;BESSER, GM
血浆皮质醇水平升高，在一个大比例的样本躁狂症患者。虽然临床躁狂症的严重程度和白天皮质醇水平的升高程度之间存在相关性，但一些临床评分低的患者皮质醇水平升高。在氟哌啶醇治疗期间，皮质醇水平恢复正常早于临床状态。讨论了潜在的机制。
Plasma cortisol levels were elevated in a large proportion of samples from manic patients. Although a correlation was found between clinial ratings of the severity of mania and the degree of elevation of daytime cortisol levels, some patients with low clinical ratings had elevated cortisol levels. During treatment with haloperidol, cortisol levels returned to normal earlier than the clinical state. The underlying mechanisms are discussed.