Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling.
Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling.
复制标题
小染色体维持6通过调节dusp6介导的ERK/GSK-3β/Snail1信号传导抑制肾纤维化。
DOI：
10.1016/j.isci.2023.107940
复制
发表时间：
2023-10-20
期刊：
影响因子：
5.8
通讯作者：
Zhang, Chun
中科院分区：
文献类型：
--
作者：
Huang, Jing;Xu, Zhi-Feng;Liu, Feng;Song, An-Ni;Su, Hua;Zhang, Chun
Minichromosome maintenance 6 (MCM6) has been implicated in the progression of various malignant tumors; however, its exact physiological function in kidney diseases remains unclear. Here, we demonstrated that MCM6 levels showed a significant increase in the proximal tubular cells during progressive renal fibrosis in two unrelated in vivo fibrotic models, including unilateral ureteral obstruction (UUO) and unilateral ischemia-reperfusion injury (UIRI). Depletion of MCM6 aggravated partial epithelial-mesenchymal transition, extracellular matrix accumulation, and myofibroblast activation in the kidneys of UUO or UIRI mice. Conversely, overexpression of MCM6 promoted the recovery of E-cadherin and retarded UUO- or UIRI-induced renal fibrosis. In addition, DUSP6 expression substantially decreased in fibrotic kidneys, and it might be involved in MCM6-induced renal fibrosis by regulating the activation of ERK/GSK-3β/Snail1 signaling. In conclusion, our results highlight the significance of MCM6 in renal fibrosis, providing a potential therapeutic target for patients with chronic kidney disease. Tubular injury triggers the upregulation of MCM6 in proximal TECs DUSP6 expression is substantially decreased in fibrotic kidneys MCM6 contributes to the activation of DUSP6-mediated ERK/GSK-3β/Snail1 signaling MCM6 level is crucial for tubular partial EMT and renal fibrogenesis Fibrosis; Gene network; Molecular interaction; Model organism
登录
查看更多内容
肾纤维化进展中组蛋白脱乙酰基酶和抑制剂的分子机制。
影响因子：
5
作者：
通讯作者：
--
MCM6通过MEK/ERK途径促进肝细胞癌的转移，并作为早期复发的新型血清生物标志物。
DOI：
10.1186/s13046-017-0669-z
发表时间：
2018-01-22
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Liu M;Hu Q;Tu M;Wang X;Yang Z;Yang G;Luo R
通讯作者：
Luo R
影响因子：
4.1
作者：
Wahab, Nadia;Cox, Dimity;Mason, Roger M.
通讯作者：
Mason, Roger M.
影响因子：
9
作者：
Qi R;Wang J;Jiang Y;Qiu Y;Xu M;Rong R;Zhu T
通讯作者：
Zhu T
影响因子：
81.5
作者：
Romagnani, Paola;Remuzzi, Giuseppe;Anders, Hans-Joachim
通讯作者：
Anders, Hans-Joachim