Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region
Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region
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DOI：
10.1016/0896-6273(95)90018-7
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发表时间：
1995-12-01
期刊：
影响因子：
16.2
通讯作者：
Landau, EM
中科院分区：
文献类型：
--
作者：
Blitzer, RD;Wong, T;Landau, EM
在海马 CAI 区域研究了 cAMP 通路在 LTP 中的作用。宽间隔的高频刺激序列通过 NMDA 受体和钙调蛋白在突触后产生 cAMP，与 Ca2+/钙调蛋白介导的突触后腺苷酸环化酶刺激一致。由相同模式的高频刺激产生的LTP的早期阶段依赖于突触后cAMP，然而，突触后应用cAMP并没有增加突触传递。当突触后注射蛋白磷酸酶抑制剂时，早期 LTP 变得不依赖于 cAMP。这些观察结果表明，在早期 LTP 中，cAMP 信号通路不是传递产生 LTP 的信号，而是通过突触后蛋白磷酸酶控制 LTP。
The role of the cAMP pathway in LTP was studied in the CAI region of hippocampus. Widely spaced trains of high frequency stimulation generated cAMP postsynaptically via NMDA receptors and calmodulin, consistent with the Ca2+/calmodulin-mediated stimulation of postsynaptic adenylyl cyclase. The early phase of LTP produced by the same pattern of high frequency stimulation was dependent an postsynaptic cAMP, However, synaptic transmission was not increased by postsynaptic application of cAMP. Early LTP became cAMP-independent when protein phosphatase inhibitors were injected postsynaptically. These observations indicate that in early LTP the cAMP signaling pathway, instead of transmitting signals for the generation of LTP, gates LTP through postsynaptic protein phosphatases.