Increased mortality among sleepy snorers:: a prospective population based study
Increased mortality among sleepy snorers:: a prospective population based study
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DOI：
10.1136/thx.53.8.631
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发表时间：
1998-08-01
期刊：
影响因子：
10
通讯作者：
Boman, G
中科院分区：
文献类型：
--
作者：
Lindberg, E;Janson, C;Boman, G
打鼾和睡眠呼吸暂停综合征的长期健康后果仍然不确定。进行这项研究，以评估与打鼾和过度白天嗜睡（EDS），两个主要症状的睡眠呼吸暂停综合征，在MEMBERS. Methods，在1984年的样本3100名男性年龄在30-69回答了邮政问卷调查，包括打鼾，EDS，和各种疾病的患病率（响应率77.1%）的问题。1985-1995年期间的死亡率数据收集的完整sample.Results-During 10年随访期间213人死亡，88心血管疾病。与1984年没有打鼾或EDS的受试者相比，单独打鼾或EDS的男性死亡率没有显着增加。打鼾和EDS的结合与死亡率的显著增加相关。然而，相对死亡率随着年龄的增加而下降，60岁及以上的男性对死亡率没有影响。60岁以下同时患有打鼾和EDS的男性的年龄调整后总死亡率是没有打鼾或EDS的男性的2.7倍（95%CI 1.6至4.5）。对于同时伴有打鼾和EDS的受试者，心血管死亡率的相应年龄校正风险比为2.9（95%CI 1.3至6.7）。进一步调整体重指数和报告的高血压、心脏病和糖尿病，将打鼾和EDS联合相关的相对死亡率风险降低至2.2（95%CI 1.3至3.8），心血管死亡率的相对风险降低至2.0（95%CI 0.8至4.7）。打鼾和EDS的结合似乎与死亡率增加有关，但其影响似乎与年龄有关。死亡率增加的部分原因是“打鼾和EDS”与心血管疾病之间的联系。
Background-The long term health consequences of snoring and sleep apnoea syndrome are still uncertain. This study was conducted to assess the mortality risk associated with snoring and excessive daytime sleepiness (EDS), the two main symptoms of sleep apnoea syndrome, in men.Methods-In 1984 a sample of 3100 men aged 30-69 responded to a postal questionnaire including questions about snoring, EDS, and the prevalence of various diseases (response rate 77.1%). Mortality data for the period 1985-1995 were collected for the complete sample.Results-During the 10 year follow up period 213 men died, 88 of cardiovascular diseases. Compared with subjects with no snoring or EDS in 1984, men with isolated snoring or EDS displayed no significantly increased mortality. The combination of snoring and EDS was associated with a significant increase in mortality. However, the relative rates decreased with increasing age, and in men aged 60 and above no effect on mortality was found. Men below the age of 60 with both snoring and EDS had an age adjusted total death rate which was 2.7 times higher than men with no snoring or EDS (95% CI 1.6 to 4.5). The corresponding age adjusted hazard ratio for cardiovascular mortality was 2.9 (95% CI 1.3 to 6.7) for subjects with both snoring and EDS. Further adjustment for body mass index and reported hypertension, cardiac disease, and diabetes reduced the relative mortality risk associated with the combination of snoring and EDS to 2.2 (95% CI 1.3 to 3.8) and the relative risk of cardiovascular mortality to 2.0 (95% CI 0.8 to 4.7).Conclusion-Snoring without EDS does not appear to carry an increased risk of mortality. The combination of snoring and EDS appears to be associated with an increased mortality rate, but the effects seems to be age dependent. The increased mortality is partly explained by an association between "snoring and EDS" and cardiovascular disease.