PAIN THRESHOLD CHANGES IN ADJUVANT-INDUCED INFLAMMATION - A POSSIBLE MODEL OF CHRONIC PAIN IN THE MOUSE
PAIN THRESHOLD CHANGES IN ADJUVANT-INDUCED INFLAMMATION - A POSSIBLE MODEL OF CHRONIC PAIN IN THE MOUSE
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DOI：
10.1016/0091-3057(86)90043-2
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发表时间：
1986-01-01
影响因子：
3.6
通讯作者：
WALSER, MM
中科院分区：
文献类型：
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作者：
LARSON, AA;BROWN, DR;WALSER, MM
通过将弗氏完全佐剂（FCA）注射到下腰椎区域或直接注射到后足垫中，在小鼠中诱导慢性痛觉过敏状况。尽管在大鼠或小鼠的下腰椎区域单次皮内注射FCA后观察到很少或没有可见的炎症，但通过甩尾和热板试验中反应潜伏期的减少确定，每个种属中的伤害性阈值均发生了显著变化。小鼠单侧足底内给予FCA导致胫跗（踝）关节区域出现可见炎症。在炎症关节周围的区域中的有害刺激的反应潜伏期的变化与在非炎症肢体中观察到的那些相似，这表明对有害刺激的敏感性的变化不仅仅是炎症组织的局部超敏反应的结果，也可能是由于中枢神经系统（CNS）水平的伤害感受的改变。 当通过组织学和形态学技术评价小鼠胫跗关节中诱导的慢性炎症状况时，发现其具有与大鼠中FCA诱导的关节炎的早期阶段中所描述的相同的特征。大鼠和小鼠对FCA的反应之间的相似性表明，在小鼠中注射FCA可能被证明是研究小鼠和大鼠慢性疼痛的有用模型。
A chronic hyperalgesic condition was induced in mice by the injection of Freund''s complete adjuvant (FCA) into the lower lumbar region or directly into the hind footpads. Although little or no visible inflammation was observed after a single intradermal injection of FCA into the lower lumbar area of rats or mice, significant alterations in nociceptive thresholds occurred in each species as determined by decreases in response latency in tail-flick and hot-plate assays. Unilateral intraplantar administration of FCA in mice resulted in visible inflammation in the area of the tibiotarsal (ankle) joint. Changes in the response latency to a noxious stimulus in the areas surrounding the inflamed joint were similar to those observed in non-inflamed limbs, suggesting that changes in sensitivity to noxious stimuli were not merely the result of local hypersensitivity of the inflamed tissue, but may also be due to alterations in nociception at the level of the central nervous system (CNS). When the chronic inflammatory condition induced in the mouse tibiotarsal joint was evaluated by histological and morphological techniques, it was found to have the same characteristics as described in the early stages of FCA-induced arthritis in rats. The similarities between the response to FCA in rat and mouse suggest that injection of FCA in mice may prove to be a useful model for the study of chronic pain in mice as well as in rats.