Intestinal adaptation to dietary calcium restriction: in vivo cecal and colonic calcium transport in the rat.
Intestinal adaptation to dietary calcium restriction: in vivo cecal and colonic calcium transport in the rat.
复制标题
肠道对饮食钙限制的适应：大鼠体内盲肠和结肠钙转运。
DOI：
10.1016/s0016-5085(76)80055-8
复制
发表时间：
1976
期刊：
影响因子：
29.4
通讯作者：
H. Schedl
中科院分区：
文献类型：
--
作者：
M. Petith;H. Schedl
小肠钙转运适应膳食钙限制，但回肠对钙的保存是不完整的。为了研究大肠在钙稳态中的作用，体重匹配的生长大鼠被放置在含有1.2%或0.02%钙的半合成饮食中。3至4周后，通过灌注0.4、0.8或3.4 mM钙溶液，在体内研究盲肠和结肠（大肠，不包括盲肠和直肠远端）的净钙运动。在摄入1.2%钙的动物中，盲肠在0.8 mM处积极吸收钙；除3.4 mM外，结肠呈净分泌。限钙动物盲肠在所有浓度下均有吸收；结肠在0.4 mM时减少分泌，在0.8 mM时转化为净吸收，在3.4 mM时大大增加净吸收。这些观察结果表明，大肠可能在钙稳态中起作用，特别是在饮食钙受到限制的情况下。
Small intestinal calcium transport adapts to dietary calcium restriction, but conservation of calcium by the ileum is incomplete. To examine the role of large intestine in calcium homeostasis, weight-matched growing rats were placed on semisynthetic diets containing 1.2 or 0.02% calcium. After 3 to 4 weeks, net calcium movements in cecum and colon (large bowel excluding cecum and distal rectum) were studied in vivo by perfusing a 0.4, 0.8, or 3.4 mM calcium solution. In animals taking 1.2% calcium, the cecum absorbed calcium actively at 0.8 mM; the colon showed net secretion except at 3.4 mM. In calcium-restricted animals, the cecum absorbed at all concentrations; the colon reduced secretion at 0.4 mM, converted to net absorption at 0.8 mM, and greatly increased net absorption at 3.4 mM. These observations suggest that the large intestine may have a role in calcium homeostasis, particularly when dietary calcium is restricted.