Intact differentiation of responses to socially-relevant emotional stimuli across psychotic disorders: An event-related potential (ERP) study.
Intact differentiation of responses to socially-relevant emotional stimuli across psychotic disorders: An event-related potential (ERP) study.
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DOI：
10.1016/j.schres.2022.06.033
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发表时间：
2022-08
影响因子：
4.5
通讯作者：
Horan, William P.
中科院分区：
文献类型：
--
作者：
Clayson, Peter E.;Wynn, Jonathan K.;Jimenez, Amy M.;Reavis, Eric A.;Lee, Junghee;Green, Michael F.;Horan, William P.
关键词：
精神分裂症患者动机注意的事件相关电位(ERP)研究通常显示出对描述不同类型内容的情感图像与非情感图像的完整敏感性。然而，还不知道这种事件相关电位模式：1)扩展到仅描述社交内容的图像，(2)适用于患有不同精神障碍的广泛样本，以及(3)与自我报告的特质社交快感缺失有关。我们检测了97名患有各种精神障碍的稳定门诊患者和38名健康对照的晚期正电位(LPP)幅度，这些图像涉及正常愉快(附属)、不愉快(威胁)或中性的人。尽管患者总体LPP较低，但两组患者对愉快和不愉快图像的LPP增强程度与中性图像相似。在患者内部，不同亚组(精神分裂症与其他精神障碍；情感性与非情感性精神病)在价态效应(愉快/不愉快与中性)方面没有显著的LPP差异。在所有组中，较高的社交快感缺乏与较低的LPP与愉快的形象显示出较小而显著的关系。这些发现表明，对社会形象的完整动机关注在精神障碍亚群中延伸。维度诊断分析显示，自我报告的特质、社交快感缺失和LPP指数之间存在适度的关联，LPP指数反映的是对愉快的附属图像的神经敏感性。
Event-related potential (ERP) studies of motivated attention in schizophrenia typically show intact sensitivity to affective vs. non-affective images depicting diverse types of content. However, it is not known whether this ERP pattern: 1) extends to images that solely depict social content, (2) applies across a broad sample with diverse psychotic disorders, and (3) relates to self-reported trait social anhedonia. We examined late positive potential (LPP) amplitudes to images involving people that were normatively pleasant (affiliative), unpleasant (threatening), or neutral in 97 stable outpatients with various psychotic disorders and 38 healthy controls. Both groups showed enhanced LPP to pleasant and unpleasant vs. neutral images to a similar degree, despite lower overall LPP in patients. Within the patients, there were no significant LPP differences among subgroups (schizophrenia vs. other psychotic disorders; affective vs. non-affective psychosis) for the valence effect (pleasant/unpleasant vs. neutral). Higher social anhedonia showed a small, significant relation to lower LPP to pleasant images across all groups. These findings suggest intact motivated attention to social images extends across psychotic disorder subgroups. Dimensional transdiagnostic analyses revealed a modest association between self-reported trait social anhedonia and an LPP index of neural sensitivity to pleasant affiliative images.
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