Fine‐needle aspiration cytology of pulmonary adenocarcinoma of fetal type: Report of a case with lmmunohistochemical and ultrastructural studies
Fine‐needle aspiration cytology of pulmonary adenocarcinoma of fetal type: Report of a case with lmmunohistochemical and ultrastructural studies
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胎儿型肺腺癌的细针抽吸细胞学检查：一例免疫组织化学和超微结构研究报告
DOI：
10.1002/dc.2840070414
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发表时间：
1991
影响因子：
1.3
通讯作者：
N. Cho
中科院分区：
文献类型：
--
作者：
Kwang‐Gil Lee;N. Cho
本报告描述了一例 53 岁男性类似胎儿肺腺癌的细针抽吸 (FNA) 细胞学检查，这是一种非常罕见的肺部恶性肿瘤，类似于肺分化的早期阶段。 FNA 涂片显示相对较小、相当均匀的肿瘤细胞表现为粘性细胞群和分散的孤立细胞，其中一些呈现玫瑰花结或腺泡图案。此外，具有嗜酸性细胞质和突出核仁的较大细胞簇与小细胞相邻或分开存在。细胞学检查结果提示可能存在异常类型的腺癌、类癌和肺母细胞瘤。对切除的肿瘤组织进行的免疫组织化学研究显示，甲胎蛋白、神经元特异性烯醇化酶和生长抑素具有免疫反应性，并且在超微结构中发现了内分泌型颗粒。这种类型的腺癌被认为具有与肺母细胞瘤相似的组织发生。据我们所知，这是细胞学文献中首次报道的病例。
This report describes the fine‐needle aspiration (FNA) cytology of a case of adenocarcinoma resembling fetal lung in a 53‐yr‐old male, a very uncommon malignant tumor of the lung that is similar to an early stage of lung differentiation. FNA smears revealed relatively small, fairly uniform tumor cells appearing as cohesive cell groups and scattered, isolated cells, some of them showing a rosette or acinus pattern. In addition, clusters of larger cells with eosinophilic cytoplasm and prominent nucleoli existed contiguously with the small cells or separately. The possibilities of an unusual type of adenocarcinoma, carcinoid tumor, and pulmonary blastoma were suggested by the cytologic findings. Immunohistochemical studies performed on a resected tumor tissue showed irnmunoreactivity for α‐fetoprotein, neuron‐specific enolase, and somatostatin, and endocrine‐type granules were found ultrastructurally. This type of adenocarcinoma is considered to have a histogenesis similar to that of pulmonary blastoma. To our knowledge this is the first reported case in the cytologic literature.