Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.
Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol.
复制标题
拉丁美洲跨祖先强迫症基因组学倡议 (LATINO)：研究方案。
DOI：
10.1101/2023.02.23.23286373
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
LatinAmericanTrans-ancestryINitiativeforOCDgenomics(
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文献类型：
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作者：
Crowley,JamesJ;Cappi,Carolina;Ochoa-Panaifo,MarcosE;Frederick,ReneeM;Kook,Minjee;Wiese,AndrewD;Rancourt,Diana;Atkinson,ElizabethG;Giusti-Rodriguez,Paola;Anderberg,JaceyL;LatinAmericanTrans-ancestryINitiativeforOCDgenomics(
强迫症（OCD）是一种使人衰弱的精神疾病。在世界范围内，其患病率约为2%，其病因尚不清楚。识别导致强迫症的生物学因素将阐明潜在的机制，并可能有助于改善治疗效果。强迫症的基因组研究开始揭示长期寻找的风险位点，但目前分析的病例中有95%是同质的欧洲血统。如果不加以解决，这种以欧洲为中心的偏见将导致强迫症基因组研究结果对欧洲血统的个体比对其他血统的个体更准确，从而在基因组学的潜在未来应用中造成健康差异。在这篇研究方案论文中，我们描述了拉丁美洲强迫症基因组学跨祖先倡议（LATINO, https://www.latinostudy.org）。LATINO是一个由来自拉丁美洲、美国和加拿大的研究人员组成的新网络，他们已经开始以文化敏感和道德的方式收集5000例拉丁美洲血统的丰富表现型强迫症病例的DNA和临床数据。在这个项目中，我们将利用跨祖先基因组分析来加速强迫症风险位点的识别，精细绘制假定的因果变异，并提高多基因风险评分在不同人群中的表现。我们还将利用丰富的临床数据来检查治疗反应的遗传学，生物学上合理的强迫症亚型和症状维度。此外，LATINO将通过与拉丁美洲研究人员合作开发和提供的各种培训，帮助阐明不同文化中强迫症临床表现的多样性。我们相信这项研究将促进全球心理健康发现和公平的重要目标。
Obsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long‐sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans‐ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans‐ancestry genomic analyses to accelerate the identification of OCD risk loci, fine‐map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.