Novel adaptive and innate immunity targets in hypertension.
Novel adaptive and innate immunity targets in hypertension.
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DOI：
10.1016/j.phrs.2017.03.015
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发表时间：
2017-06
影响因子：
9.3
通讯作者：
Mattson DL
中科院分区：
文献类型：
--
作者：
Abais-Battad JM;Dasinger JH;Fehrenbach DJ;Mattson DL
高血压是一种世界性流行病和全球健康问题，因为它是心血管疾病发展的主要危险因素。免疫系统与其在高血压发病机制中的作用之间的关系早已建立，但过去几年的实质性进展已经剖析了特定的因果分子机制。本文将简要介绍这些最近的研究探索参与先天性或适应性免疫途径。待讨论的这些途径包括先天免疫因子，如抗原呈递细胞和模式识别受体，适应性免疫元件，包括T和B淋巴细胞，更具体地说，T调节细胞的新兴作用，以及细胞因子和趋化因子作为连接先天免疫和适应性免疫的信号信使的潜力。总之，我们总结了这些研究提供了新的视角，希望能导致更有针对性的方法来操纵免疫系统作为高血压治疗。
Hypertension is a worldwide epidemic and global health concern as it is a major risk factor for the development of cardiovascular diseases. A relationship between the immune system and its contributing role to the pathogenesis of hypertension has been long established, but substantial advancements within the last few years have dissected specific causal molecular mechanisms. This review will briefly examine these recent studies exploring the involvement of either innate or adaptive immunity pathways. Such pathways to be discussed include innate immunity factors such as antigen presenting cells and pattern recognition receptors, adaptive immune elements including T and B lymphocytes, and more specifically, the emerging role of T regulatory cells, as well as the potential of cytokines and chemokines to serve as signaling messengers connecting innate and adaptive immunity. Together, we summarize these studies to provide new perspective for what will hopefully lead to more targeted approaches to manipulate the immune system as hypertensive therapy.