Visual event-related potentials in schizotypal personality disorder and schizophrenia.
Visual event-related potentials in schizotypal personality disorder and schizophrenia.
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DOI：
10.1037/0021-843x.117.1.119
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发表时间：
2008-02
影响因子：
4.6
通讯作者：
Jenifer L. Vohs;W. Hetrick;Paul D. Kieffaber;Misty Bodkins;Andrew W. Bismark;A. Shekhar;B. O’Donnell
中科院分区：
文献类型：
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作者：
Jenifer L. Vohs;W. Hetrick;Paul D. Kieffaber;Misty Bodkins;Andrew W. Bismark;A. Shekhar;B. O’Donnell
Schizophrenia (SZ) occurs among a spectrum of disorders with similar characteristics, including schizotypal personality disorder (SPD). Visual processing disturbances have been reported in both disorders, but it is not yet clear which processes are disturbed in both SZ and SPD, suggestive of a common endophenotype, and which appear only in SZ. In order to address this question, the authors evaluated visual event-related potentials (ERPs) elicited during a line-orientation discrimination task in control, SPD, and SZ participants. Visual ERPs allow specification of both the time course and physiological correlates of visual perception and cognition. SZ patients had smaller P100 and P300a amplitudes and prolonged P300b latency compared to the control group. SZ patients also had smaller N160, N200, P300a, and P300b amplitudes compared to the SPD group. SPD participants did not differ from control participants on any ERP measure. These data documented pervasive abnormalities in visual perception and attention in SZ but not in SPD, suggesting that these visual ERP disturbances may not represent a common endophenotype.
