Phenotypic consequences of logarithmic signaling in MAPK stress response.
Phenotypic consequences of logarithmic signaling in MAPK stress response.
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MAPK 应激反应中对数信号传导的表型后果。
DOI：
10.1101/2023.12.05.570188
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Neuert,Gregor
中科院分区：
文献类型：
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作者：
Jashnsaz,Hossein;Neuert,Gregor
细胞对动态环境变化的反应是理解基本生物过程和细胞生理学的关键。在这项研究中，我们开发了一个实验和定量分析框架，以探索随时间变化的动态应力梯度如何调节细胞体积、信号激活和生长表型。我们的研究结果表明，与传统的急性应激相比，逐渐的应激条件大大促进了细胞的生长。这种生长优势与依赖于应力动态的细胞体积的最小减少有关。我们通过发现酵母有丝分裂原激活蛋白激酶（MAPK）渗透胁迫反应途径中的对数信号转导机制来解释生长表型。这些对渐进环境、细胞体积变化、动态细胞信号和生长之间相互作用的见解，促进了我们对渐进应激环境下基本细胞过程的理解。
How cells respond to dynamic environmental changes is crucial for understanding fundamental biological processes and cell physiology. In this study, we developed an experimental and quantitative analytical framework to explore how dynamic stress gradients that change over time regulate cellular volume, signaling activation, and growth phenotypes. Our findings reveal that gradual stress conditions substantially enhance cell growth compared to conventional acute stress. This growth advantage correlates with a minimal reduction in cell volume dependent on the dynamic of stress. We explain the growth phenotype with our finding of a logarithmic signal transduction mechanism in the yeast mitogen-activated protein kinase (MAPK) osmotic stress response pathway. These insights into the interplay between gradual environments, cell volume change, dynamic cell signaling, and growth, advance our understanding of fundamental cellular processes in gradual stress environments.