The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia
The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia
复制标题
DOI：
10.1046/j.1365-2141.2001.03140.x
复制
发表时间：
2001-12-01
影响因子：
6.5
通讯作者：
Falcao, RP
中科院分区：
文献类型：
--
作者：
Franco, RF;Simöes, BP;Falcao, RP
我们确定了71例（小于或等于15岁）急性淋巴细胞白血病（ALL）患儿和71例对照患者中亚甲基四氢叶酸还原酶（MTHFR）突变C677T和A1298C的患病率。与MTHFR C677T相关的ALL的优势比（OR）为0.4 (95% CI 0.2-0.8)；杂合子的OR为0.5 (95%CI 0.2-0.9)，纯合子的OR为0.3 (95%CI 0.09-0.8)， MTHFR A1298C对AIL的总体OR为1.3 (95%CI 0.7-2.6)；杂合子为1.3 (95% CI: 0.7-7.6)，纯合子为2.8 （95% CI: 0.5-15.6）。总之，MTHFR C677T与儿童ALL发病风险显著降低2.4倍有关，而MTHFR A1298C对我们人群中ALL发病风险没有显著影响。
We have determined the prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations C677T and A1298C in 71 children (less than or equal to 15 years) with acute lymphoblastic leukaemia (ALL) and in 71 control subjects. Odds ratio (OR) for ALL linked to MTHFR C677T was 0.4 (95% CI 0.2-0.8); for heterozygotes it was 0.5 (95% CI 0.2-0.9) and for homozygotes it was 0.3 (95%CI 0.09-0.8), MTHFR A1298C yielded an overall OR for AIL of 1.3 (95% CI: 0.7-2.6); for heterozygotes it was 1.3 (95% CI: 0.7-7.6) and for homozygotes it was 2.8 (95% CI 0.5-15.6). In conclusion, MTHFR C677T was linked to a significant 2.4-fold decreased risk of developing childhood ALL, whereas MTHFR A1298C did not significantly affect the risk of ALL in our population.