An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor
An injectable drug-loaded hydrogel using a “clickable” amphiphilic triblock copolymer as a precursor
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我们开发了一种简单的策略来制备具有化学交联的可注射载药水凝胶。采用缩聚和开环聚合相结合的方法，“一锅法”合成了PCL-POEGM-PCL两亲性三嵌段共聚物，该共聚物可将疏水性药物分散在水溶液中，并在生理条件下与POEGMS交联。
We developed a facile strategy to prepare an injectable drug-loaded hydrogel with chemical crosslinkages. A PCL-POEGM-PCL amphiphilic triblock copolymer was synthesized in “one pot” by a combination of polycondensation and ring-opening polymerization, which can disperse hydrophobic drugs in aqueous solution and be crosslinked by POEGMS under physiological conditions.