Long-term facilitation of breathing is absent after episodes of hypercapnic hypoxia in awake humans
Long-term facilitation of breathing is absent after episodes of hypercapnic hypoxia in awake humans
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DOI：
10.1016/j.resp.2006.08.011
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发表时间：
2007-05-14
影响因子：
2.3
通讯作者：
Duffin, James
中科院分区：
文献类型：
--
作者：
Diep, Tu Tuan;Khan, Tuba Rashid;Duffin, James
尽管许多先前的研究人员未能证明清醒人类缺氧发作后呼吸的长期促进作用，但我们尝试使用类似于阻塞性睡眠呼吸暂停患者经历的高碳酸血症缺氧发作模式来产生它，推断如果长期促进作用与这些患者相关，那么测试此类发作的有效性是适当的。从大学生群体中抽取的十名受试者被用来测量通气量、心率和呼气末。坐在舒适的躺椅上，逐次呼吸 P-CO2 和 P-O2。在呼吸室内空气的初始休息期后，他们经历了 15 次、30 秒的呼吸 6% O-2 和 5% CO2 的事件，中间间隔 90 秒的呼吸空气。我们在事件发生后一小时检查了测量变量，但没有发现通气量增加或潮气末 P-CO2 减少的趋势，这表明存在长期促进作用。因此，我们得出的结论是，在清醒的人中使用这种刺激模式并没有证明可以长期促进通气。 (c) 2006 Elsevier B.V. 保留所有权利。
Despite the failure by many previous investigators to demonstrate a long-term facilitation of breathing following episodes of hypoxia in awake humans, we attempted to produce it using a pattern of hypercapnic hypoxic episodes similar to that experienced by obstructive sleep apnoea patients, reasoning that if long-term facilitation was relevant to these patients then it is appropriate to test the effectiveness of such episodes.Ten subjects drawn from the University student population were instrumented to measure ventilation, heart rate and end-tidal P-CO2 and P-O2 breath-by-breath while seated in a comfortable reclining chair. After an initial resting period breathing room air they experienced fifteen, 30-S episodes breathing 6% O-2 and 5% CO2 separated by 90 s of breathing air.We examined the measured variables for an hour after the episodes but found no trends toward an increase in ventilation or decrease in endtidal P-CO2 that would indicate the presence of a long-term facilitation. We therefore concluded that long-term facilitation of ventilation was not demonstrated in awake humans using this pattern of stimuli. (c) 2006 Elsevier B.V. All rights reserved.