Total Synthesis of (-)-Cinatrin C-1 Based on an In(OTf)(3)-Catalyzed Conia-Ene Reaction
Total Synthesis of (-)-Cinatrin C-1 Based on an In(OTf)(3)-Catalyzed Conia-Ene Reaction
复制标题
基于 In(OTf)(3) 催化 Conia-Ene 反应全合成 (-)-Cinatrin C-1
DOI：
10.1021/jo400263w
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发表时间：
2013
影响因子：
3.6
通讯作者：
Jun; Hatakeyama Susumi
中科院分区：
文献类型：
--
作者：
Urabe;Fumiya; Nagashima;Shunsuke; Takahashi;Keisuke;Ishihara;Jun; Hatakeyama Susumi
完成了磷脂酶A2抑制剂（-）-cinatrin C1的立体控制全合成。的关键特征包括立体选择性建设的高度取代的四氢呋喃核心，通过在（OTf）3-催化Conia-烯反应的氧栓系的炔属丙二酸酯，然后通过二羟基化伴随内酯化。
The stereocontrolled total synthesis of (−)-cinatrin C1, a phospholipase A2inhibitor, has been accomplished. The key feature includes the stereoselective construction of the highly substituted tetrahydrofuran core by In(OTf)3-catalyzed Conia–ene reaction of the oxygen-tethered acetylenic malonic ester followed by dihydroxylation with concomitant lactonization.