Skin sensory innervation patterns in embryonic chick hindlimb following dorsal root ganglion reversals.
Skin sensory innervation patterns in embryonic chick hindlimb following dorsal root ganglion reversals.
复制标题
背根神经节逆转后胚胎鸡后肢的皮肤感觉神经支配模式。
DOI：
10.1002/neu.480170609
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Scott,SA
中科院分区：
文献类型：
--
作者：
Scott,SA
在胚胎发育过程中，小鸡腰骶背根神经节 (DRG) 中的皮肤感觉神经元以精确、有序的方式建立其皮节和轴突投射。为了研究导致这种特定生长的机制，通过单独旋转或与 St. 15-16 胚胎中的底层神经管一起旋转神经嵴的相应部分，反转 DRG T7-LS3 的轴尾顺序。由此产生的皮肤感觉神经支配模式，在生理学或解剖学上绘制在第 29-40 阶段，在两个实验组之间是不同的。神经管旋转后，DRG 倾向于建立与其在胚胎中的原始位置一致的神经支配模式。来自这些旋转的 DRG 的轴突通常投射到适当的通路并支配皮肤的适当区域。神经嵴旋转使腹侧神经管（包括运动神经元前体）基本完好无损。在这种情况下，旋转的 DRG 倾向于根据它们在胚胎中的新位置建立神经支配模式，几乎就像没有进行旋转一样。这些结果不能仅仅用感觉神经元固有的特异性来解释。相反，结果与运动轴突可以指导感觉轴突的生长并从而影响感觉神经支配模式的建立的建议（Honig et al., 1986; Landmesser and Honig, 1986）基本一致。讨论了也可能影响感觉神经支配模式发展的其他机制。
During embryonic development skin sensory neurons in lumbosacral dorsal root ganglia (DRGs) establish their dermatomes and axonal projections in a precise, orderly fashion in the chick. To investigate mechanisms responsible for this specific outgrowth, the rostrocaudal order of DRGs T7-LS3 was reversed by rotating the corresponding segments of neural crest, either alone or together with the underlying neural tube in St. 15–16 embryos. The resulting skin sensory innervation patterns, mapped physiologically or an-atomically at St. 29–40, differed between the two experimental groups. Following neural tube rotations DRGs tended to establish innervation patterns that were consonant with their original position in the embryo. Axons from these rotated DRGs generally projected into the appropriate pathways and innervated the appopriate region of skin. Neural crest rotations left the ventral neural tube (including the motor neuron precursors) largely intact. In this case rotated DRGs tended to establish innervation patterns in accordance with their new position in the embryo, almost as if no rotation had been made. These results cannot be explained solely by the inherent specificity of sensory neurons. Instead, the results are largely consistent with the suggestion (Honig et al., 1986; Landmesser and Honig, 1986) that motor axons can direct the outgrowth of sensory axons and thereby influence the establishment of sensory innervation patterns. Other mechanisms that may also affect the development of sensory innervation patterns are discussed.