Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin's lymphoma autografted after a first relapse
Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin's lymphoma autografted after a first relapse
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DOI：
10.1093/annonc/mdi119
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发表时间：
2005-04-01
影响因子：
50.5
通讯作者：
Conde, E
中科院分区：
文献类型：
--
作者：
Sureda, A;Constans, A;Conde, E
目的：分析357例首次复发后接受自体干细胞移植（ASCT）的霍奇金淋巴瘤（HL）患者的总生存期（OS）和至治疗失败时间（TTF）的结局和预后因素，并报告给The Grupo EspaNol de Linfomas/ Trasplante AutOlogo de Medula Osea（GEL/TAMO）合作小组。220名男性和137名女性，中位年龄为29岁，在第二次缓解期接受自体移植结果：5年TTF和OS分别为49% 3%和57% 3%。诊断时的晚期、ASCT前的补充放疗、ASCT时的短期首次完全缓解（CR）和可检测疾病对TTF有不利影响。移植年= 1 ASCT涉及的淋巴结区域是OS的不利因素。结论：ASCT构成HL患者首次复发后的治疗选择。在诊断时肿瘤负荷低、长时间CR后自体移植且ASCT时未检测到疾病的患者中观察到有希望的结果。对于有复发风险因素的患者，应采取创新方法。
Purpose: To analyse outcome and prognostic factors for overall survival (OS) and time to treatment failure (TTF) in 357 patients with Hodgkin's lymphoma (HL) undergoing an autologous stem cell transplantation (ASCT) after a first relapse and reported to the The Grupo EspaNol de Linfomas/ Trasplante AutOlogo de MEdula Osea (GEL/TAMO) Cooperative Group.Methods: Two hundred and twenty mates and 137 females with a median age of 29 years were autografted in second remission (n = 18 1), first sensitive relapse (n = 148) and first resistant relapse (n = 28).Results: Five-year actuarial TTF and OS were of 49% 3% and 57% 3%. Advanced stage at diagnosis, complementary radiotherapy before ASCT, a short first complete response (CR) and detectable disease at ASCT adversely influenced TTF. Year of transplant = 1 extranodal areas involved at ASCT were adverse factors for OS.Conclusions: ASCT constitutes a therapeutic option for HL patients after a first relapse. Promising results are observed in patients with low tumour burden at diagnosis, autografted after a long CR and without detectable disease at ASCT. Innovative approaches should be pursued for patients with risk factors at relapse.