Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU): Experience With 1249 VLUs in 897 Patients.
Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU): Experience With 1249 VLUs in 897 Patients.
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DOI：
10.1016/j.jccw.2016.01.001
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发表时间：
2014-12-01
期刊：
影响因子：
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通讯作者：
Bongiovanni, Cheryl M
中科院分区：
文献类型：
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作者：
Bongiovanni, Cheryl M
为了评估合并症的影响和确定加速静脉性小腿溃疡愈合率的因素，我们对我们在不同人群中的经验进行了广泛的回顾分析。2006年6月至2014年6月，莱克创伤诊所共收治897例患者1249处静脉性小腿溃疡。治疗方案采用了伤口清洁、清创和加压包扎的标准方案。小腿静脉性溃疡的伤口清洁、自溶清创、包扎和敷料使用次氯酸(HCA)水溶液，而不是标准的生理盐水。这个方案使所有的溃疡完全愈合。延迟愈合的合并症包括糖尿病未得到控制或控制不佳、晚期外周动脉闭塞症(PAD)、经常吸烟、使用类固醇药物和/或街头药物、初始溃疡面积大和深度显著。其他因素，包括高龄、反复出现的静脉溃疡、淤积性皮炎、脂肪皮肤病、病态肥胖和感染一种或多种耐多药微生物，并未推迟关闭。从这一经验中，我们得出结论，静脉腿部溃疡护理方案，即清洁，清创，包装和次氯酸溶液穿衣可以减少一些并发症的影响，同时加快愈合时间。文中还介绍了其他好处。
In order to assess the impact of comorbidities and identify factors that accelerate the healing rate of venous leg ulcers we performed an extensive, retrospective analysis of our experience in a diverse population. From June, 2006 to June, 2014, 897 patients with 1249 venous leg ulcers were treated at Lake Wound Clinics. Treatment protocols utilized the standard regimen of wound cleaning, debridement and compression bandaging. Wound cleaning, autolytic debridement, packing and dressing of venous leg ulcers utilized aqueous solutions of hypochlorous acid (HCA) rather than the standard normal saline. This protocol caused all ulcers to close completely. Comorbidities that delayed healing included uncontrolled or poorly controlled diabetes mellitus, advanced peripheral artery occlusive disease (PAD), active smoking, use of steroid medications and/or street drugs, large initial ulcer size and significant depth. Other factors, including advanced age, recurrent venous ulceration, stasis dermatitis, lipodermatosclerosis, morbid obesity and infection with one or more multidrug resistant organisms did not delay closure. From this experience we conclude that venous leg ulcer care protocols that clean, debride, pack and dress with hypochlorous acid solutions can reduce the effects of some comorbidities while accelerating healing times. Additional benefits are described.