An artificial metalloenzyme for olefin metathesis
An artificial metalloenzyme for olefin metathesis
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DOI：
10.1039/c1cc15005g
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Hilvert, Donald
中科院分区：
文献类型：
--
作者：
Mayer, Clemens;Gillingham, Dennis G.;Hilvert, Donald
一个Grubbs-Hoveyda型烯烃复分解催化剂，配备了亲电溴乙酰胺基团，被用来修改一个小的热休克蛋白的一个含半胱氨酸的变体从詹氏甲烷球菌。发现所得的人工金属酶在基准闭环复分解反应中在酸性条件下具有活性。
A Grubbs-Hoveyda type olefin metathesis catalyst, equipped with an electrophilic bromoacetamide group, was used to modify a cysteine-containing variant of a small heat shock protein from Methanocaldococcus jannaschii. The resulting artificial metalloenzyme was found to be active under acidic conditions in a benchmark ring closing metathesis reaction.