Microwave-Assisted Nanonization of Poorly Water-Soluble Curcumin
Microwave-Assisted Nanonization of Poorly Water-Soluble Curcumin
复制标题
DOI：
10.1021/acssuschemeng.8b06377
复制
发表时间：
2019-06-03
影响因子：
8.4
通讯作者：
Norton, Ian T.
中科院分区：
文献类型：
--
作者：
Aditya, Nayak P.;Hamilton, Ian E.;Norton, Ian T.
纳米化是一种经常用于提高水溶性的技术，从而提高难溶性分子的生物利用度。这种生物利用度的改善是由于物理化学性质的变化，如表面/体积比，润湿性等。在这项工作中，材料的具体耦合和体积加热性能的微波被利用，以实现高度的过饱和和成核，通过快速，均匀地蒸发溶剂从溶剂和反溶剂的二元混合物。这导致形成悬浮在反溶剂中的纳米尺寸的姜黄素纳米颗粒。纳米化导致姜黄素纳米颗粒的形成，其类似于160 nm的大小。通过扫描电子显微镜在视觉上确认纳米颗粒的球形形状。通过应用这种方法，我们设法将大的多分散姜黄素晶体转化为结晶度大大降低的纳米颗粒。这通过在XRD研究中从10-30度（2 θ）的谱线中姜黄素的特征尖峰的降低和通过DSC研究观察到的熔融焓的降低来证明。因此，它可能增加姜黄素的表观溶解度、溶解速度和口服生物利用度。这增加了其在食品和药品中的使用。利用乙醇和水等绿色溶剂，发展了微波辅助纳米化技术.这将导致可持续纳米技术在食品和制药应用方面的发展发生重大变化。
Nanonization is a technology that is often used to enhance aqueous solubility and thus improve bioavailability of poorly soluble molecules. This improvement in bioavailability is due to changes in physicochemical properties such as surface/volume ratio, wettability etc. In this work, material specific coupling and volumetric heating properties of microwaves were utilized to achieve a high degree of supersaturation and nucleation by rapidly and uniformly evaporating the solvent from the binary mixture of solvent and antisolvent. This resulted in the formation of nanosized curcumin nanoparticles suspended in the antisolvent. Nanonization resulted in the formation of curcumin nanoparticles which were similar to 160 nm size. The spherical shape of the nanoparticles was visually confirmed by scanning electron microscopy. By applying this approach, we managed to convert large polydispersed curcumin crystals into nanoparticles with considerably decreased crystallinity. This was demonstrated by the decrease in the curcumin's characteristic sharp peaks in the spectral line from 10-30 degrees (2 theta) in the XRD studies and reduced enthalpy of melting as observed by DSC studies. As a consequence of this, it potentially increases the apparent solubility, dissolution velocity and oral bioavailability of curcumin. This increases its use in both food and pharmaceutical products. Microwave- assisted nanonization technology has been developed using green solvents like ethanol and water. This should lead to a step change in the development of sustainable nanotechnology for food and pharmaceutical application.