CT-monitored percutaneous cryoablation in a pig liver model: Pilot study
CT-monitored percutaneous cryoablation in a pig liver model: Pilot study
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DOI：
10.1148/radiology.211.3.r99jn29687
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发表时间：
1999-06-01
期刊：
影响因子：
19.7
通讯作者：
Mahvi, DM
中科院分区：
文献类型：
--
作者：
Lee, FT;Chosy, SG;Mahvi, DM
PURPOSE: To determine the safety and feasibility of percutaneous cryoablation with computed tomographic (CT) guidance in a pig liver model.MATERIALS AND METHODS: Nine angiographic balloons (mean diameter, 9 mm) were placed in the livers of seven domestic pigs (mean weight, 30.0 kg +/- 14.0 [SD]) as tumor-mimicking lesions. By using ultrasonographic and CT guidance, two 2.4- or 3.0-mm cryoprobes were placed flanking the balloon, and a 15-20-minute freezing process was performed. Hemostasis was achieved;by placing absorbable cellulose fabric down the probe tract. After 24-96 hours, animals were sacrificed, and their livers were removed and were sectioned axially at 5-mm intervals for comparison with CT images.RESULTS: All animals survived the procedure-without complication. No serious hemorrhage was found in any case. Ice balls were readily visualized at CT because they appeared as areas of decreased attenuation (1.0 HU +/- 20.7) when compared with areas of normal liver (48.2 HU +/- 6.3, P < .05). The mean ablative margin was 1.7 cm, and only one of nine cases, the one with probe failure, had a positive margin. Beam-hardening artifact from the metal probes was present but did not interfere with the procedure, ice-ball size and shape corresponded closely to the area of necrosis determined;at histopathologic analysis.CONCLUSION: CT-monitored percutaneous cryoablation is feasible-and safe in this pig liver model.
